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Methods in Molecular Biology

Target Identification and Validation in Drug Discovery

Methods and Protocols

Editors: Moll, Jürgen, Carotta, Sebastian (Eds.)

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  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts
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eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4939-9145-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-4939-9144-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This second edition book explores breakthrough technologies in the field of drug target identification and validation. The volume emphasizes particularly revolutionary technologies, such as CRISPR-related screening, “big data,” and in silico approaches, as well as in vivo applications of CRISPR and best uses of animal models in drug development. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 
Fully updated and authoritative, Target Identification and Validation in Drug Discovery: Methods and Protocols, Second Edition is an ideal guide for molecular and cellular biologists, pharmacologists, pathologists, bioinformaticians, clinical researchers, or investigators, as well as experts in other fields that need a quick overview of these state-of-the-art technologies.

Table of contents (19 chapters)

Table of contents (19 chapters)
  • Using Functional Genetics in Haploid Cells for Drug Target Identification

    Pages 3-21

    Volz, Jennifer C. (et al.)

  • Unbiased Forward Genetic Screening with Chemical Mutagenesis to Uncover Drug–Target Interactions

    Pages 23-31

    Horn, Moritz (et al.)

  • Integration of RNAi and Small Molecule Screens to Identify Targets for Drug Development

    Pages 33-42

    Drosopoulos, Konstantinos (et al.)

  • CellProfiler and KNIME: Open-Source Tools for High-Content Screening

    Pages 43-60

    Stöter, Martin (et al.)

  • In Silico Target Druggability Assessment: From Structural to Systemic Approaches

    Pages 63-88

    Trosset, Jean-Yves (et al.)

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4939-9145-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-4939-9144-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Target Identification and Validation in Drug Discovery
Book Subtitle
Methods and Protocols
Editors
  • Jürgen Moll
  • Sebastian Carotta
Series Title
Methods in Molecular Biology
Series Volume
1953
Copyright
2019
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-4939-9145-7
DOI
10.1007/978-1-4939-9145-7
Hardcover ISBN
978-1-4939-9144-0
Series ISSN
1064-3745
Edition Number
2
Number of Pages
XIII, 318
Number of Illustrations
11 b/w illustrations, 29 illustrations in colour
Topics