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Methods in Molecular Biology

Fragile-X Syndrome

Methods and Protocols

Editors: Ben-Yosef, Dalit, Mayshar, Yoav (Eds.)

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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eBook $149.00
price for USA in USD (gross)
  • ISBN 978-1-4939-9080-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-1-4939-9079-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume discusses the latest technologies used to study all aspects of Fragile-X Syndrome (FXS). The chapters in this book cover topics such as monitoring for epigenetic modifications at the FMR1 locus; modeling FXS with human pluripotent stem cells, mouse neural progenitors; mouse versus human-based models for FXS pre-clinical research; and Fragile-X associated with Tremor/Ataxia Syndrome (FXTAS). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, Fragile-X Syndrome: Methods and Protocols is a valuable tool to help scientists working towards one day developing a therapeutic solution to improve the symptoms of FXS.
Chapter "Induced Neurons for the Study of Neurodegenerative and Neurodevelopmental Disorders" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Reviews

“The main audience is basic scientists involved in laboratory medicine, but there is enough clinical information to attract the attention of clinicians. Clinical geneticists may find it interesting as the questions asked by current technology provide answers to the phenotypic clinical variances observed. Graduate students involved in fragile X syndrome would find this book essential. … The illustrations are well selected and appropriate.” (Luis F Escobar, Doody's Book Reviews, June 07, 2019)

Table of contents (15 chapters)

Table of contents (15 chapters)
  • Fragile X Syndrome: Introduction

    Pages 3-10

    Reches, Adi

  • Clinical Genetic Testing for Fragile X Syndrome by Polymerase Chain Reaction Amplification and Southern Blot Analyses

    Pages 11-27

    Cai, Xiaoqiang (et al.)

  • Monitoring for Epigenetic Modifications at the FMR1 Locus

    Pages 29-48

    Epsztejn-Litman, Silvina (et al.)

  • Assays for Determining Repeat Number, Methylation Status, and AGG Interruptions in the Fragile X-Related Disorders

    Pages 49-59

    Hayward, Bruce E. (et al.)

  • One-Step Generation of Seamless Luciferase Gene Knockin Using CRISPR/Cas9 Genome Editing in Human Pluripotent Stem Cells

    Pages 61-69

    Li, Meng (et al.)

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-1-4939-9080-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-1-4939-9079-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Fragile-X Syndrome
Book Subtitle
Methods and Protocols
Editors
  • Dalit Ben-Yosef
  • Yoav Mayshar
Series Title
Methods in Molecular Biology
Series Volume
1942
Copyright
2019
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-4939-9080-1
DOI
10.1007/978-1-4939-9080-1
Hardcover ISBN
978-1-4939-9079-5
Series ISSN
1064-3745
Edition Number
1
Number of Pages
X, 192
Number of Illustrations
10 b/w illustrations, 15 illustrations in colour
Topics