Computational Methods for Drug Repurposing

Front Matter

Methods for Discovering and Targeting Druggable Protein-Protein Interfaces and Their Application to Repurposing

• E. Sila Ozdemir, Farideh Halakou, Ruth Nussinov, Attila Gursoy, Ozlem Keskin

Performing an In Silico Repurposing of Existing Drugs by Combining Virtual Screening and Molecular Dynamics Simulation

• Farzin Sohraby, Milad Bagheri, Hassan Aryapour

Repurposing Drugs Based on Evolutionary Relationships Between Targets of Approved Drugs and Proteins of Interest

• Sohini Chakraborti, Gayatri Ramakrishnan, Narayanaswamy Srinivasan

Drug Repositioning by Mining Adverse Event Data in ClinicalTrials.gov

• Eric Wen Su

Transcriptomic Data Mining and Repurposing for Computational Drug Discovery

• Yunguan Wang, Jaswanth Yella, Anil G. Jegga

Network-Based Drug Repositioning: Approaches, Resources, and Research Directions

• Salvatore Alaimo, Alfredo Pulvirenti

A Computational Bipartite Graph-Based Drug Repurposing Method

• Si Zheng, Hetong Ma, Jiayang Wang, Jiao Li

Implementation of a Pipeline Using Disease-Disease Associations for Computational Drug Repurposing

• Preethi Balasundaram, Rohini Kanagavelu, Nivya James, Sayoni Maiti, Shanthi Veerappapillai, Ramanathan Karuppaswamy

An Application of Computational Drug Repurposing Based on Transcriptomic Signatures

• Evangelos Karatzas, George Kolios, George M. Spyrou

Drug-Induced Expression-Based Computational Repurposing of Small Molecules Affecting Transcription Factor Activity

• Kaitlyn Gayvert, Olivier Elemento

A Drug Repurposing Method Based on Drug-Drug Interaction Networks and Using Energy Model Layouts

• Mihai Udrescu, Lucreţia Udrescu

Integrating Biological Networks for Drug Target Prediction and Prioritization

• Xiao Ji, Johannes M. Freudenberg, Pankaj Agarwal

Using Drug Expression Profiles and Machine Learning Approach for Drug Repurposing

• Kai Zhao, Hon-Cheong So

Computational Prediction of Drug-Target Interactions via Ensemble Learning

• Ali Ezzat, Min Wu, Xiaoli Li, Chee-Keong Kwoh

A Machine-Learning-Based Drug Repurposing Approach Using Baseline Regularization

• Zhaobin Kuang, Yujia Bao, James Thomson, Michael Caldwell, Peggy Peissig, Ron Stewart et al.

Machine Learning Approach for Predicting New Uses of Existing Drugs and Evaluation of Their Reliabilities

• Yutaka Fukuoka

A Drug-Target Network-Based Supervised Machine Learning Repurposing Method Allowing the Use of Multiple Heterogeneous Information Sources

• André C. A. Nascimento, Ricardo B. C. Prudêncio, Ivan G. Costa

Heter-LP: A Heterogeneous Label Propagation Method for Drug Repositioning

• Maryam Lotfi Shahreza, Nasser Ghadiri, James R. Green

Tripartite Network-Based Repurposing Method Using Deep Learning to Compute Similarities for Drug-Target Prediction

• Nansu Zong, Rachael Sze Nga Wong, Victoria Ngo