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Suicide Gene Therapy

Methods and Protocols

  • Book
  • © 2019

Overview

Editors:
  1. Nejat Düzgüneş

    1. Department of Biomedical Sciences, Arthur A. Dugoni School of Dentistry, University of the Pacific, San Francisco, USA

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  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1895)

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Table of contents (14 protocols)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Origins of Suicide Gene Therapy

    • Nejat Düzgüneş
    Pages 1-9

  3. Cancer Suicide Gene Therapy with TK.007

    • Jubayer A. Hossain, Kristoffer Riecken, Hrvoje Miletic, Boris Fehse
    Pages 11-26

  4. Osteonectin Promoter-Mediated Suicide Gene Therapy of Prostate Cancer

    • Wan-Chi Hsiao, Shian-Ying Sung, Leland W. K. Chung, Chia-Ling Hsieh
    Pages 27-42

  5. Suicide Gene Therapy for Oral Squamous Cell Carcinoma

    • Henrique Faneca, Nejat Düzgüneş, Maria C. Pedroso de Lima
    Pages 43-55

  6. Generation of Suicide Gene-Modified Chimeric Antigen Receptor-Redirected T-Cells for Cancer Immunotherapy

    • Kentaro Minagawa, Mustafa Al-Obaidi, Antonio Di Stasi
    Pages 57-73

  7. Mesenchymal Stem Cell Exosome-Mediated Prodrug Gene Therapy for Cancer

    • Cestmir Altaner, Ursula Altanerova
    Pages 75-85

  8. Extracellular Vesicles as Carriers of Suicide mRNA and/or Protein in Cancer Therapy

    • Erdogan Pekcan Erkan, Nurten Saydam, Clark C. Chen, Okay Saydam
    Pages 87-96

  9. Production of Viral Vectors with Suicide Genes by Utilizing the Intron-Splicing Mechanism of Insect Cells

    • Haifeng Chen
    Pages 97-109

  10. Resveratrol-Responsive CArG Elements from the Egr-1 Promoter for the Induction of GADD45α to Arrest the G2/M Transition

    • Qiwen Shi, Deepak Bhatia
    Pages 111-122

  11. Noninvasive Monitoring of Suicide Gene Therapy by Using Multimodal Molecular Imaging

    • Bryan Holvoet, Cindy Leten, Christophe M. Deroose, Uwe Himmelreich
    Pages 123-134

  12. In Vitro Assay for the Evaluation of Cytotoxic Effects Provided by a Combination of Suicide and Killer Genes in a Bicistronic Vector

    • Alexey A. Komissarov, Sergey V. Kostrov, Ilya V. Demidyuk
    Pages 135-147

  13. Engineered Thymidine-Active Deoxycytidine Kinase for Bystander Killing of Malignant Cells

    • Anton Neschadim, Jeffrey A. Medin
    Pages 149-163

  14. Photochemical Internalization Enhanced Nonviral Suicide Gene Therapy

    • Chung-Ho Sun, Kristian Berg, Henry Hirschberg
    Pages 165-176

  15. Suicide Gene Therapy of Oral Squamous Cell Carcinoma and Cervical Carcinoma In Vitro

    • Nejat Düzgüneş, Jennifer Cheung, Krystyna Konopka
    Pages 177-184

  16. Back Matter

    Pages 185-190
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Keywords

About this book

This detailed volume explores the methods used for most of the recent approaches to suicide gene therapy of cancer, which exploits promoters that are specific to cancer cells, thereby ensuring (or greatly increasing the likelihood) that the therapeutic gene is expressed only in cancer cells. The book also contains chapters describing methods to improve the safety of cell therapy and techniques utilizing bone marrow mesenchymal cells. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.  

Authoritative and practical, Suicide Gene Therapy: Methods and Protocols serves as an ideal guide for researchers expanding upon our knowledge and application of this vital form of cancer therapy.

Editors and Affiliations

  • Department of Biomedical Sciences, Arthur A. Dugoni School of Dentistry, University of the Pacific, San Francisco, USA

    Nejat Düzgüneş

Bibliographic Information

  • Book Title: Suicide Gene Therapy

  • Book Subtitle: Methods and Protocols

  • Editors: Nejat Düzgüneş

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-8922-5

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2019

  • Hardcover ISBN: 978-1-4939-8921-8Published: 12 December 2018

  • eBook ISBN: 978-1-4939-8922-5Published: 11 December 2018

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XII, 190

  • Number of Illustrations: 11 b/w illustrations, 26 illustrations in colour

  • Topics: Gene Therapy, Cancer Research, Molecular Medicine

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