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Methods in Molecular Biology

Protein Misfolding Diseases

Methods and Protocols

Editors: Gomes, Cláudio M. (Ed.)

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  • Includes cutting-edge methods and protocols for the study of protein folding diseases
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4939-8820-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-4939-8819-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: November 2, 2019
  • ISBN 978-1-4939-9396-3
  • Free shipping for individuals worldwide
About this book

This detailed book gathers a broad collection of experimental approaches to assist researchers in setting up different methods to investigate protein conformational disorders. Beginning with a section on assays focusing on biophysical approaches to study protein (mis)folding, the volume continues with sections on cellular and proteostasis assays as well as assays for protein folding correction and recovery, combining methods such as thermal shift assays, in silico improvement of protein solubility, and compound screening, an important area of research as it may open avenues for therapeutic strategies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. 
Authoritative and practical, Protein Misfolding Diseases: Methods and Protocols serves as an ideal guide for researchers seeking to advance our knowledge of protein conformational disorders.

Table of contents (21 chapters)

Table of contents (21 chapters)
  • Biophysical and Spectroscopic Methods for Monitoring Protein Misfolding and Amyloid Aggregation

    Pages 3-18

    Cristóvão, Joana S. (et al.)

  • Ultrasensitive RT-QuIC Seed Amplification Assays for Disease-Associated Tau, α-Synuclein, and Prion Aggregates

    Pages 19-37

    Saijo, Eri (et al.)

  • Vesicle-Based Assays to Study Membrane Interactions of Amyloid Peptides

    Pages 39-51

    Malishev, Ravit (et al.)

  • Differential Scanning Fluorimetry and Hydrogen Deuterium Exchange Mass Spectrometry to Monitor the Conformational Dynamics of NBD1 in Cystic Fibrosis

    Pages 53-67

    Soya, Naoto (et al.)

  • A Multipronged Method for Unveiling Subtle Structural–Functional Defects of Mutant Chaperone Molecules Causing Human Chaperonopathies

    Pages 69-92

    Bulone, Donatella (et al.)

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4939-8820-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-1-4939-8819-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: November 2, 2019
  • ISBN 978-1-4939-9396-3
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Protein Misfolding Diseases
Book Subtitle
Methods and Protocols
Editors
  • Cláudio M. Gomes
Series Title
Methods in Molecular Biology
Series Volume
1873
Copyright
2019
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-4939-8820-4
DOI
10.1007/978-1-4939-8820-4
Hardcover ISBN
978-1-4939-8819-8
Softcover ISBN
978-1-4939-9396-3
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XIII, 338
Number of Illustrations
19 b/w illustrations, 58 illustrations in colour
Topics