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Methods in Molecular Biology

The LINC Complex

Methods and Protocols

Editors: Gundersen, Gregg G, Worman, Howard J (Eds.)

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  • Includes cutting-edge methods and protocols 
  • Provides step-by-step detail essential for reproducible results 
  • Contains key notes and implementation advice from the experts
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  • ISBN 978-1-4939-8691-0
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About this book

This volume describes research methodologies and approaches used to study the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex and its cellular functions. Chapters detail structural and biochemical analysis of LINC complexes, mechanical aspects of the LINC complex, analysis of the LINC complex in model systems and development, and LINC complex in mammalian tissue, organs, and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, The LINC Complex: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Table of contents (22 chapters)

Table of contents (22 chapters)
  • EM Tomography of Meiotic LINC Complexes

    Pages 3-15

    Spindler, Marie-Christin (et al.)

  • Recombinant Purification of the Periplasmic Portion of the LINC Complex

    Pages 17-23

    Cruz, Victor E. (et al.)

  • Analysis of High Molecular Weight Isoforms of Nesprin-1 and Nesprin-2 with Vertical Agarose Gel Electrophoresis

    Pages 25-33

    Potter, Chloe (et al.)

  • Analysis of Nesprin-2 Interaction with Its Binding Partners and Actin

    Pages 35-43

    Antoku, Susumu (et al.)

  • Interactions of Nesprin-4-Containing LINC Complexes in Outer Hair Cells Explored by BioID

    Pages 45-56

    Burke, Brian

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-1-4939-8691-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
Softcover $219.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
The LINC Complex
Book Subtitle
Methods and Protocols
Editors
  • Gregg G Gundersen
  • Howard J Worman
Series Title
Methods in Molecular Biology
Series Volume
1840
Copyright
2018
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-4939-8691-0
DOI
10.1007/978-1-4939-8691-0
Hardcover ISBN
978-1-4939-8690-3
Softcover ISBN
978-1-4939-9367-3
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XIV, 338
Number of Illustrations
20 b/w illustrations, 41 illustrations in colour
Topics

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