Methods in Molecular Biology

Rational Drug Design

Methods and Protocols

Editors: Mavromoustakos, Thomas, Kellici, Tahsin F. (Eds.)

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key note and implementation advice from the expert
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About this book

This volume covers several aspects of rational drug design, such as synthesis of novel bioactive drugs; development and application of new methodologies; computational methods valuable for the establishment of new approaches in drug discovery; and the effects of physical-chemical and ADMET properties of the designed potential drugs. Chapters guide readers through amyloid deposits, Saturation Transfer Difference (STD) NMR, methods on bioguided design, the importance of lipophilicity in drug design, ADMET, FRET, structural biology, and homology modeling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Rational Drug Design: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Table of contents (27 chapters)

Table of contents (27 chapters)
  • Molecular Dynamics Simulations on the Bioactive Molecule of hIAPP22–29 (NFGAILSS) and Rational Drug Design

    Lagarias, Panagiotis (et al.)

    Pages 1-16

  • Development of Peptide-Based Inhibitors of Amylin Aggregation Employing Aromatic and Electrostatic Repulsion

    Profit, Adam A. (et al.)

    Pages 17-31

  • In Silico Drug Design: Non-peptide Mimetics for the Immunotherapy of Multiple Sclerosis

    Tzoupis, Haralambos (et al.)

    Pages 33-47

  • Binding Moiety Mapping by Saturation Transfer Difference NMR

    Brender, Jeffrey R. (et al.)

    Pages 49-65

  • Protein-Ligand Docking in Drug Design: Performance Assessment and Binding-Pose Selection

    Ballante, Flavio

    Pages 67-88

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-1-4939-8630-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-1-4939-8629-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Rational Drug Design
Book Subtitle
Methods and Protocols
Editors
  • Thomas Mavromoustakos
  • Tahsin F. Kellici
Series Title
Methods in Molecular Biology
Series Volume
1824
Copyright
2018
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-4939-8630-9
DOI
10.1007/978-1-4939-8630-9
Hardcover ISBN
978-1-4939-8629-3
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XIV, 465
Number of Illustrations
24 b/w illustrations, 124 illustrations in colour
Topics