Core Concepts in Acute Kidney Injury

1. Front Matter

   Pages i-xii

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2. Epidemiology and Diagnosis

   1. Front Matter

      Pages 1-1

      PDF

   2. Epidemiology, Incidence, Risk Factors, and Outcomes of Acute Kidney Injury

      • Marlies Ostermann

      Pages 3-11

   3. Definition and Classification of Acute Kidney Injury

      • Kelly V. Liang, Paul M. Palevsky

      Pages 13-22

   4. Diagnostic Approach: Differential Diagnosis, Physical Exam, Lab Tests, Imaging, and Novel Biomarkers

      • Aparna Sharma, Jay L. Koyner

      Pages 23-42

3. Pathophysiology

   1. Front Matter

      Pages 43-43

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   2. Overview of Pathophysiology of Acute Kidney Injury: Human Evidence, Mechanisms, Pathological Correlations and Biomarkers and Animal Models

      • Timothy J. Pianta, Glenda C. Gobe, Evan P. Owens, Zoltan H. Endre

      Pages 45-67

   3. Tubular Physiology in Acute Kidney Injury: Cell Signalling, Injury and Inflammation

      • David A. Ferenbach, Eoin D. O’Sullivan, Joseph V. Bonventre

      Pages 69-91

4. Clinical Syndromes

   1. Front Matter

      Pages 93-93

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   2. Contrast-Associated Acute Kidney Injury

      • Steven D. Weisbord

      Pages 95-112

   3. Acute Kidney Injury and Liver Disease: Incidence, Pathophysiology, Prevention/Treatment, and Outcomes

      • Justin M. Belcher, Chirag R. Parikh

      Pages 113-131

   4. Acute Kidney Injury and Cancer: Incidence, Pathophysiology, Prevention/Treatment, and Outcomes

      • Colm C. Magee

      Pages 133-143

   5. Drug-Induced Acute Kidney Injury

      • Randy L. Luciano, Mark A. Perazella

      Pages 145-163

   6. Sepsis and Acute Kidney Injury: Epidemiology, Pathophysiology, Diagnosis, and Management

      • Rashid Alobaidi, Sean M. Bagshaw

      Pages 165-180

   7. Acute Kidney Failure and Minimal Change Disease

      • Alain Meyrier, Patrick Niaudet

      Pages 181-193

   8. Core Concepts: Post-cardiac Surgery Acute Kidney Injury

      • Jason B. O’Neal, Frederic T. Billings IV, Andrew D. Shaw

      Pages 195-202

   9. Rare and Overlooked Causes of Acute Kidney Injury

      • José A. Morfín, Shruti Gupta

      Pages 203-219

   10. Acute Kidney Injury in the Tropics: Epidemiology, Presentation, Etiology, Specific Diseases, and Treatment

       • Sreejith Parameswaran, Vivekanand Jha

       Pages 221-235

   11. Pediatric Acute Kidney Injury: Diagnosis, Epidemiology, and Treatment

       • Elizabeth A. K. Hunt, Michael A. Ferguson

       Pages 237-246

   12. Post-renal Acute Kidney Injury: Epidemiology, Presentation, Pathophysiology, Diagnosis, and Management

       • Valary T. Raup, Steven L. Chang, Jairam R. Eswara

       Pages 247-256

This comprehensive guide covers the causes, characteristics, and presentations of acute kidney injury (AKI), as well as prevention and treatment. The first part of the book features chapters on the epidemiology and diagnosis of AKI. This is followed by sections on pathophysiology, clinical syndromes and patient management. Authored by leading clinicians, epidemiologists, basic scientists, and clinical trialists, this book captures the latest evidence and best practices for treating patients with AKI.

• Acute Renal Failure
• Hemodialytic
• Oncologic
• Replacement Therapy
• Sepsis

• Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA

  Sushrut S. Waikar, Ajay K. Singh

• University College Dublin, Dublin, Ireland

  Patrick T. Murray

Ajay K. Singh, MB, MRCP, MBA, Renal Division, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, USA
Sushrut S. Waikar, MD, MPH, Renal Division, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, USA



Patrick Murray, MD
Dean of Medicine & Head of School
University College Dublin School of Medicine & Medical Science
Dublin, Ireland

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