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Analysis of Drugs of Abuse

  • Book
  • © 2018

Overview

Editors:
  1. Rabi A. Musah

    1. Department of Chemistry, State University of New York at Albany, Albany, USA

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1810)

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Table of contents (19 protocols)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Color Tests for the Preliminary Identification of New Psychoactive Substances

    • Kaitlyn Toole, Morgan Philp, Nadine Krayem, Shanlin Fu, Ronald Shimmon, Sonia Taflaga
    Pages 1-11

  3. Illicit and Counterfeit Drug Analysis by Morphologically Directed Raman Spectroscopy

    • Andrew C. Koutrakos, Pauline E. Leary, Brooke W. Kammrath
    Pages 13-27

  4. Analysis of Drugs of Abuse by Gas Chromatography–Mass Spectrometry (GC-MS)

    • Thomas A. Brettell, Benny J. Lum
    Pages 29-42

  5. Toward Confirmatory On-Site Real-Time Detection of Emerging Drugs Using Portable Ultrafast Capillary Electrophoresis Mass Spectrometry

    • Mehdi Moini
    Pages 43-58

  6. Use of DART-TOF-MS for Screening Drugs of Abuse

    • Robert R. Steiner
    Pages 59-68

  7. Confirmation of Pharmaceutical Identifiers via DART-TOF-MS

    • Jacob Easter
    Pages 69-74

  8. UPLC-Orbitrap® Screening for over 35 Drugs of Abuse and Metabolites in Biological Fluids in Under 10 min

    • Eshwar Jagerdeo, Jason E. Schaff
    Pages 75-87

  9. Sensitivity Enhancement in Capillary Electrophoresis Using Magnetic Particles as Solid-Phase Extraction Sorbents for the Determination of Drugs of Abuse in Urine

    • Tatiana Baciu, Francesc Borrull, Carme Aguilar, Marta Calull
    Pages 89-96

  10. High-Throughput Extraction and Detection of Drugs in Urine: Parallel Sampling with Solid-Phase Microextraction (SPME) Fibers Coupled with Direct Analysis in Real Time-Mass Spectrometry (DART-MS) Detection

    • Frederick Li, Brian Musselman
    Pages 97-106

  11. Analysis of Drugs of Abuse in Hair Samples by Ultrahigh-Performance Liquid Chromatography–Tandem Mass Spectrometry (UHPLC-MS/MS)

    • D. Di Corcia, A. Salomone, E. Gerace
    Pages 107-114

  12. Comprehensive Drug Screening by Thermal Desorption and Pyrolysis Combined with Direct Analysis in Real Time-Mass Spectrometry (TDP/DART-MS)

    • Hiroko Abe, Chikako Takei, Motoshi Sakakura, Daisuke Yajima, Hirotato Iwase
    Pages 115-124

  13. Detection of Diagnostic Plant-Derived Psychoactive Biomarkers in Fingerprints by MALDI-SpiralTOF-Mass Spectrometry Imaging

    • Cameron M. Longo, Rabi A. Musah
    Pages 125-132

  14. Matrix-Assisted Laser Desorption Ionization Imaging Mass Spectrometry of Drug Distribution in Mouse Brain Tissue by High-Resolution Time-of-Flight Mass Spectrometry

    • Takaya Satoh, Ayumi Kubo, Hisanao Hazama
    Pages 133-139

  15. Estimation of Community Usage of Drugs Utilizing Sewage Epidemiology

    • Bikram Subedi
    Pages 141-147

  16. LC-MS-MS Method Development and Analysis of Stimulants, Opiates, Synthetic Opiates, PCP, and Benzodiazepines in Wastewater. Preponderance of these Drugs During Football Games

    • Waseem Gul, Shahbaz W. Gul, Brandon Stamper, Murrell Godfrey, Mahmoud A. ElSohly
    Pages 149-182

  17. Analysis of Illicit Drugs in Wastewater Using High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (HPLC-ESI-MS/MS)

    • Katelyn S. Foppe, Bikram Subedi
    Pages 183-191

  18. Analysis of Trace Drugs of Abuse by Direct Analysis in Real Time (DART) Mass Spectrometry

    • David D. Cunningham
    Pages 193-205

  19. A Rapid, High-Throughput Validated Method for the Quantification of Atropine in Datura stramonium Seeds Using Direct Analysis in Real Time-High Resolution Mass Spectrometry (DART-HRMS)

    • Ashton D. Lesiak, Kristen L. Fowble, Rabi A. Musah
    Pages 207-215

  20. Utilizing Direct Analysis in Real Time-High Resolution Mass Spectrometry-Derived Dark Matter Spectra to Classify and Identify Unknown Synthetic Cathinones

    • Kristen L. Fowble, Rabi A. Musah
    Pages 217-225
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Keywords

About this book

This volume features a comprehensive set of protocols featuring a range of both old and new technologies that can be used to analyze drugs of abuse, including prescription drugs, new psychoactive substances and psychoactive plants. Chapters guide readers through the application of color tests, light microscopy-based particle imaging, GC-MS, Raman spectroscopy, capillary electrophoresis, ultra-high performance LC-tandem MS, DART-MS, MALDI-mass spectrometry imaging, LC-MS/MS and HPLC-ESI-MS/MS to the analysis of abused drugs in wastewater, hair, urine and plant-derived materials, among other matrices. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Analysis of Drugs of Abuse aims to ensuresuccessful results in the further study of this vital field.

Editors and Affiliations

  • Department of Chemistry, State University of New York at Albany, Albany, USA

    Rabi A. Musah

Bibliographic Information

  • Book Title: Analysis of Drugs of Abuse

  • Editors: Rabi A. Musah

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-8579-1

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2018

  • Hardcover ISBN: 978-1-4939-8578-4Published: 05 July 2018

  • Softcover ISBN: 978-1-4939-9332-1Published: 10 December 2019

  • eBook ISBN: 978-1-4939-8579-1Published: 05 July 2018

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XII, 231

  • Number of Illustrations: 31 b/w illustrations, 65 illustrations in colour

  • Topics: Pharmacology/Toxicology

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