Methods in Molecular Biology

Huntington’s Disease

Editors: Precious, Sophie, Rosser, Anne, Dunnett, Stephen B. (Eds.)

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  • Includes cutting-edge techniques for the study of Huntington's Disease
  • Provides clear details essential for reproducible results
  • Contains practical insights from experts in the field
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eBook $229.00
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  • ISBN 978-1-4939-7825-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $299.99
price for USA in USD
  • ISBN 978-1-4939-7824-3
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  • Usually dispatched within 3 to 5 business days.
About this book

This detailed book provides a laboratory manual and guidebook for the selection, implementation, and interpretation of a wide range of techniques in contemporary use in leading laboratories engaged in Huntington’s disease (HD) research worldwide. Only by understanding the pathology and pathogenic process at the fundamental molecular and cellular level can the research community expect to be able to slow or halt the disease process, repair the damage, and develop novel effective therapies to treat the symptoms of this condition, thus this volume collects the practical knowledge of its authors. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 
Authoritative and invaluable, Huntington’s Disease aims to help scientists to significantly extend the breadth and quality of research in laboratories dedicated to mastering and controlling this devastating human condition.

Table of contents (29 chapters)

Table of contents (29 chapters)
  • Stereological Methods to Quantify Cell Loss in the Huntington’s Disease Human Brain

    Mehrabi, Nasim F. (et al.)

    Pages 1-16

  • Assessing Autophagic Activity and Aggregate Formation of Mutant Huntingtin in Mammalian Cells

    Stamatakou, Eleanna (et al.)

    Pages 17-29

  • A Filter Retardation Assay Facilitates the Detection and Quantification of Heat-Stable, Amyloidogenic Mutant Huntingtin Aggregates in Complex Biosamples

    Ast, Anne (et al.)

    Pages 31-40

  • Cellular Models: HD Patient-Derived Pluripotent Stem Cells

    Geater, Charlene (et al.)

    Pages 41-73

  • Nonmammalian Models of Huntington’s Disease

    Chongtham, Anjalika (et al.)

    Pages 75-96

Buy this book

eBook $229.00
price for USA in USD (gross)
  • ISBN 978-1-4939-7825-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $299.99
price for USA in USD
  • ISBN 978-1-4939-7824-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Huntington’s Disease
Editors
  • Sophie Precious
  • Anne Rosser
  • Stephen B. Dunnett
Series Title
Methods in Molecular Biology
Series Volume
1780
Copyright
2018
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-4939-7825-0
DOI
10.1007/978-1-4939-7825-0
Hardcover ISBN
978-1-4939-7824-3
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XV, 642
Number of Illustrations
37 b/w illustrations, 74 illustrations in colour
Topics