Epigenome Editing
Methods and Protocols
Editors: Jeltsch, Albert, Rots, Marianne G. (Eds.)
Free Preview- Includes cutting-edge techniques for the study of epigenome editingProvides step-by-step detail essential for reproducible results
- Contains key implementation advice from the experts
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- About this book
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This detailed book explores the concepts and applications of epigenome editing, as presented by leading scientists in the field. Beginning with some general and topical reviews, the collection continues by covering the design of DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Epigenome Editing: Methods and Protocols will be of great assistance to people new to the field but also to those already engaged, as epigenetic editing is still a relatively unexplored field with many issues to be resolved.
- Table of contents (26 chapters)
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Editing the Epigenome: Overview, Open Questions, and Directions of Future Development
Pages 3-18
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Zinc Fingers, TALEs, and CRISPR Systems: A Comparison of Tools for Epigenome Editing
Pages 19-63
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Designing Epigenome Editors: Considerations of Biochemical and Locus Specificities
Pages 65-87
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Generation of TALE-Based Designer Epigenome Modifiers
Pages 89-109
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Neuroepigenetic Editing
Pages 113-136
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Table of contents (26 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Epigenome Editing
- Book Subtitle
- Methods and Protocols
- Editors
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- Albert Jeltsch
- Marianne G. Rots
- Series Title
- Methods in Molecular Biology
- Series Volume
- 1767
- Copyright
- 2018
- Publisher
- Humana Press
- Copyright Holder
- Springer Science+Business Media, LLC, part of Springer Nature
- eBook ISBN
- 978-1-4939-7774-1
- DOI
- 10.1007/978-1-4939-7774-1
- Hardcover ISBN
- 978-1-4939-7773-4
- Softcover ISBN
- 978-1-4939-9281-2
- Series ISSN
- 1064-3745
- Edition Number
- 1
- Number of Pages
- XIV, 482
- Number of Illustrations
- 14 b/w illustrations, 69 illustrations in colour
- Topics
