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Biomarkers for Alzheimer’s Disease Drug Development

  • Book
  • © 2018

Overview

Editors:
  1. Robert Perneczky

    1. Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1750)

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Table of contents (27 protocols)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  3. Innovative Approaches to Cerebrospinal Fluid Biomarker Discovery

    1. Front Matter

      Pages 67-67
      Download chapter PDF

    2. CSF Lipidomics Analysis: High-Resolution Mass Spectrometry Analytical Platform

      • Paul L. Wood, Randall L. Woltjer
      Pages 69-74

    3. CSF N-Glycomics Using MALDI MS Techniques in Alzheimer’s Disease

      • Angelo Palmigiano, Angela Messina, Rosaria Ornella Bua, Rita Barone, Luisa Sturiale, Mario Zappia et al.
      Pages 75-91

    4. MicroRNA Profiling of Alzheimer’s Disease Cerebrospinal Fluid

      • Johannes Denk, Holger Jahn
      Pages 93-107

  4. Novel Blood-Based Biomarkers

    1. Front Matter

      Pages 109-109
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    2. Validation of a Chemiluminescence Immunoassay for Measuring Amyloid-β in Human Blood Plasma

      • Jonathan Vogelgsang, Jens Wiltfang, Hans W. Klafki
      Pages 111-124

    3. Mass Spectrometry-Based Metabolomic Multiplatform for Alzheimer’s Disease Research

      • Raúl González-Domínguez, Álvaro González-Domínguez, Ana Sayago, Ángeles Fernández-Recamales
      Pages 125-137

    4. Blood-Based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis Within the Dimensional Spectrum of Neurodegenerative Diseases

      • Filippo Baldacci, Simone Lista, Sid E. O’Bryant, Roberto Ceravolo, Nicola Toschi, Harald Hampel et al.
      Pages 139-155

  5. Magnetic Resonance Imaging Methods

    1. Front Matter

      Pages 157-157
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    2. Functional Magnetic Resonance Imaging in Alzheimer’ Disease Drug Development

      • Stefan Holiga, Ahmed Abdulkadir, Stefan Klöppel, Juergen Dukart
      Pages 159-163

    3. Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies

      • Carles Falcon, Grégory Operto, José Luis Molinuevo, Juan Domingo Gispert
      Pages 165-184

    4. Hybrid PET-MRI in Alzheimer’s Disease Research

      • Ismini C. Mainta, Maria I. Vargas, Sara Trombella, Giovanni B. Frisoni, Paul G. Unschuld, Valentina Garibotto
      Pages 185-200

  6. Molecular Imaging Approaches

    1. Front Matter

      Pages 201-201
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    2. Amyloid PET Imaging: Standardization and Integration with Other Alzheimer’s Disease Biomarkers

      • Silvia Morbelli, Matteo Bauckneht
      Pages 203-212

    3. The Use of 18F-FDG PET in the Diagnostic Workup of Alzheimer’s Dementia

      • Marion M. Ortner
      Pages 213-219
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Keywords

About this book

This volume aims to build a new generation of experts with a broader understanding of key topics in the Alzheimer’s disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation in blood-based biomarkers, a comprehensive overview of magnetic resonance imaging and molecular imaging approaches and their value for developing drugs for Alzheimer’s disease, cutting-edge developments in neuropathology and their relevance for Alzheimer’s disease trials, novel genomic strategies for biomarker development, and related topics including neuropsychological testing and advanced analytical methods.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 

Authoritative and cutting-edge, Biomarkers for Alzheimer's Disease Drug Development aims to ensure successful results in the further study of this vital field. 

Editors and Affiliations

  • Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany

    Robert Perneczky

Bibliographic Information

  • Book Title: Biomarkers for Alzheimer’s Disease Drug Development

  • Editors: Robert Perneczky

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-7704-8

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC 2018

  • Hardcover ISBN: 978-1-4939-7703-1Published: 07 March 2018

  • Softcover ISBN: 978-1-4939-9262-1Published: 14 August 2020

  • eBook ISBN: 978-1-4939-7704-8Published: 06 March 2018

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XV, 372

  • Number of Illustrations: 9 b/w illustrations, 45 illustrations in colour

  • Topics: Pharmacology/Toxicology

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