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Methods in Pharmacology and Toxicology

Drug-Induced Liver Toxicity

Editors: Chen, Minjun, Will, Yvonne (Eds.)

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  • Includes cutting-edge techniques for the study of DILI
  • Contains key implementation advice from the experts
  • Features detail essential for labs, from basic research through to clinical action
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eBook $109.00
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  • ISBN 978-1-4939-7677-5
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Hardcover $149.99
price for USA in USD
  • ISBN 978-1-4939-7676-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $149.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: April 4, 2019
  • ISBN 978-1-4939-9256-0
  • Free shipping for individuals worldwide
About this book

This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six sections, the first section introduces the mechanisms contributing to drug-induced liver toxicity.  The second and third section explore in silico and in vitro approaches used to help mitigate hepatotoxicity liability at the early stages of drug development. The fourth section describes methodologies applied in regulatory processes, including preclinical studies, clinical trials, and post-marketing surveillance. The fifth section discusses clinical hepatotoxicity. Emerging technologies are examined in the final section. As a volume in the Methods in Pharmacology and Toxicology series, chapters include the kind of expert advice that will lead to optimal results. 
Authoritative and practical, Drug-Induced Liver Toxicity serves all those who aim to improve assessment and understanding of hepatotoxic potentials of new medications and marketed drugs.

Chapter 30 is open access under a CC BY 4.0 license via link.springer.com. 

Table of contents (31 chapters)

Table of contents (31 chapters)
  • Overview of Mechanisms of Drug-Induced Liver Injury (DILI) and Key Challenges in DILI Research

    Pages 3-18

    Noureddin, Nabil (et al.)

  • Detection, Elimination, Mitigation, and Prediction of Drug-Induced Liver Injury in Drug Discovery

    Pages 21-43

    Pognan, Francois

  • Drug-Induced Liver Injury (DILI) Classification and Its Application on Human DILI Risk Prediction

    Pages 45-59

    Thakkar, Shraddha (et al.)

  • Physicochemical Properties and Structural Alerts

    Pages 61-76

    Fisk, Lilia (et al.)

  • Quantitative Structure–Activity Relationship Models for Predicting Risk of Drug-Induced Liver Injury in Humans

    Pages 77-100

    Hong, Huixiao (et al.)

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-1-4939-7677-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-1-4939-7676-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $149.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: April 4, 2019
  • ISBN 978-1-4939-9256-0
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Drug-Induced Liver Toxicity
Editors
  • Minjun Chen
  • Yvonne Will
Series Title
Methods in Pharmacology and Toxicology
Copyright
2018
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-4939-7677-5
DOI
10.1007/978-1-4939-7677-5
Hardcover ISBN
978-1-4939-7676-8
Softcover ISBN
978-1-4939-9256-0
Series ISSN
1557-2153
Edition Number
1
Number of Pages
XX, 667
Number of Illustrations
49 b/w illustrations, 70 illustrations in colour
Topics