Methods in Molecular Biology

Duchenne Muscular Dystrophy

Methods and Protocols

Editors: Bernardini, Camilla (Ed.)

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  • Includes cutting-edge methods and protocols for DMD research
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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eBook $109.00
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  • ISBN 978-1-4939-7374-3
  • Digitally watermarked, DRM-free
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Hardcover $179.99
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Softcover $139.99
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About this book

This volume explores experimental approaches used to study Duchenne muscular dystrophy (DMD), an X-linked degenerative skeletal muscle disease caused by mutations in the dystrophin gene. Including the latest progress and scientific achievements, the book covers recent discoveries achieved through in vivo gene editing which have proven to be promising in restoring dystrophin expression, at least in ameliorating skeletal muscle symptoms, and the contents focus on “Omics” techniques in gene expression, protein expression, miRNAs, and long non-coding RNA analysis, as well as experimental studies of the structural/functional changes affecting the skeletal and cardiac muscles and ongoing preclinical studies and clinical trials. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 
Authoritative and practical, Duchenne Muscular Dystrophy: Methods and Protocols serves as a guide for researchers exploring the complicated nature of dystrophin in the hope of helping the victims of this disorder.

Table of contents (20 chapters)

Table of contents (20 chapters)
  • An Overview of Recent Therapeutics Advances for Duchenne Muscular Dystrophy

    Pages 3-17

    Mah, Jean K., M.

  • Clinical Manifestations and Overall Management Strategies for Duchenne Muscular Dystrophy

    Pages 19-28

    Tsuda, Takeshi

  • Cardiac Involvement in Duchenne Muscular Dystrophy and Related Dystrophinopathies

    Pages 31-42

    Mavrogeni, Sophie I. (et al.)

  • Characterization of the Inflammatory Response in Dystrophic Muscle Using Flow Cytometry

    Pages 43-56

    Kastenschmidt, Jenna M. (et al.)

  • Imaging Analysis of the Neuromuscular Junction in Dystrophic Muscle

    Pages 57-72

    Pratt, Stephen J. P. (et al.)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-1-4939-7374-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Hardcover $179.99
price for USA in USD
Softcover $139.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Duchenne Muscular Dystrophy
Book Subtitle
Methods and Protocols
Editors
  • Camilla Bernardini
Series Title
Methods in Molecular Biology
Series Volume
1687
Copyright
2018
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media LLC
eBook ISBN
978-1-4939-7374-3
DOI
10.1007/978-1-4939-7374-3
Hardcover ISBN
978-1-4939-7373-6
Softcover ISBN
978-1-4939-8466-4
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XII, 287
Number of Illustrations
15 b/w illustrations, 34 illustrations in colour
Topics