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Characterization of Nanoparticles Intended for Drug Delivery

  • Book
  • © 2018

Overview

Editors:
  1. Scott E. McNeil

    1. Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1682)

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Table of contents (20 protocols)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Evaluating Nanomedicines: Obstacles and Advancements

      • Magdalena Swierczewska, Rachael M. Crist, Scott E. McNeil
      Pages 3-16

  3. Sterility and Endotoxin Testing

    1. Front Matter

      Pages 17-17
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    2. Detection of Bacterial Contamination in Nanoparticle Formulations by Agar Plate Test

      • Timothy M. Potter, Barry W. Neun, Anna N. Ilinskaya, Marina A. Dobrovolskaia
      Pages 19-22

    3. Considerations and Some Practical Solutions to Overcome Nanoparticle Interference with LAL Assays and to Avoid Endotoxin Contamination in Nanoformulations

      • Barry W. Neun, Marina A. Dobrovolskaia
      Pages 23-33

  4. Physicochemical Characterization

    1. Front Matter

      Pages 35-35
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    2. Elemental Analysis in Biological Matrices Using ICP-MS

      • Matthew N. Hansen, Jeffrey D. Clogston
      Pages 37-47

    3. PEG Quantitation Using Reversed-Phase High-Performance Liquid Chromatography and Charged Aerosol Detection

      • Mackensie C. Smith, Jeffrey D. Clogston
      Pages 49-55

    4. Quantitation of Surface Coating on Nanoparticles Using Thermogravimetric Analysis

      • Alpana A. Dongargaonkar, Jeffrey D. Clogston
      Pages 57-63

    5. Immunoelectron Microscopy for Visualization of Nanoparticles

      • Sarah R. Anderson, David Parmiter, Ulrich Baxa, Kunio Nagashima
      Pages 65-71

    6. Imaging of Liposomes by Transmission Electron Microscopy

      • Ulrich Baxa
      Pages 73-88

  5. Immunology

    1. Front Matter

      Pages 89-89
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    2. Updated Method for In Vitro Analysis of Nanoparticle Hemolytic Properties

      • Barry W. Neun, Anna N. Ilinskaya, Marina A. Dobrovolskaia
      Pages 91-102

    3. In Vitro Assessment of Nanoparticle Effects on Blood Coagulation

      • Timothy M. Potter, Jamie C. Rodriguez, Barry W. Neun, Anna N. Ilinskaya, Edward Cedrone, Marina A. Dobrovolskaia
      Pages 103-124

    4. In Vitro Analysis of Nanoparticle Effects on the Zymosan Uptake by Phagocytic Cells

      • Timothy M. Potter, Sarah L. Skoczen, Jamie C. Rodriguez, Barry W. Neun, Anna N. Ilinskaya, Edward Cedrone et al.
      Pages 125-133

    5. Assessing NLRP3 Inflammasome Activation by Nanoparticles

      • Bhawna Sharma, Christopher B. McLeland, Timothy M. Potter, Stephan T. Stern, Pavan P. Adiseshaiah
      Pages 135-147

    6. Analysis of Complement Activation by Nanoparticles

      • Barry W. Neun, Anna N. Ilinskaya, Marina A. Dobrovolskaia
      Pages 149-160

    7. Methods for Analysis of Nanoparticle Immunosuppressive Properties In Vitro and In Vivo

      • Timothy M. Potter, Barry W. Neun, Marina A. Dobrovolskaia
      Pages 161-172

    8. Analysis of Pro-inflammatory Cytokine and Type II Interferon Induction by Nanoparticles

      • Timothy M. Potter, Barry W. Neun, Jamie C. Rodriguez, Anna N. Ilinskaya, Marina A. Dobrovolskaia
      Pages 173-187
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Keywords

About this book

This second edition volume expands on the first edition by providing up-to-date protocols to characterize nanomaterials used as drug delivery agents. The chapters in this book are divided into 5 parts and cover topics such as: advances and obstacles in nanomedicine research; methods to test sterility and endotoxin, physicochemical features, immunological effects, drug release, and in vivo efficacy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and comprehensive, Characterization of Nanoparticles Intended for Drug Delivery, Second Edition is a valuable tool for researchers and pharmaceutical and biotechnology developers who are evaluating the clinical potential of nanomedicines in preclinical studies.>

Editors and Affiliations

  • Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA

    Scott E. McNeil

Bibliographic Information

  • Book Title: Characterization of Nanoparticles Intended for Drug Delivery

  • Editors: Scott E. McNeil

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-7352-1

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media LLC 2018

  • Hardcover ISBN: 978-1-4939-7350-7Published: 20 October 2017

  • Softcover ISBN: 978-1-4939-8460-2Published: 18 May 2018

  • eBook ISBN: 978-1-4939-7352-1Published: 17 October 2017

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: XII, 256

  • Number of Illustrations: 32 b/w illustrations, 40 illustrations in colour

  • Topics: Pharmacology/Toxicology

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