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Methods in Molecular Biology

Proteomics for Drug Discovery

Methods and Protocols

Editors: Lazar, Iulia M., Kontoyianni, Maria, Lazar, Alexandru C. (Eds.)

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  • Includes cutting-edge techniques for the study of drug discovery via proteomics
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts
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eBook $139.00
price for USA in USD (gross)
  • ISBN 978-1-4939-7201-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-1-4939-7200-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-1-4939-8414-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book reflects the drug development community’s interest in proteomics methods by providing researchers with the necessary knowledge for the implementation of a number of basic experimental and bioinformatics protocols in the drug discovery research laboratory. The focus of the collection is on select protocols and methodologies that address the analysis of post-translational modifications, targeted protein quantification, protein-protein, protein-lipid, or protein-ATP interactions, in silico lead identification, protein arrays, tissue and cell extract preparation, labeling, chemoproteomics, and drug efficacy assessment. Emphasis was placed not just on methods that describe large-scale protein analysis, but also on ones that are amenable to future implementation in a high-throughput format. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 
Practical and authoritative, Proteomics for Drug Discovery: Methods and Protocols aims to provide a deep knowledge of the fundamentals of disease biology as well the means that were developed for probing the complex biological milieu.

Table of contents (20 chapters)

Table of contents (20 chapters)
  • A Photoaffinity Labeling-Based Chemoproteomics Strategy for Unbiased Target Deconvolution of Small Molecule Drug Candidates

    Thomas, Jason R. (et al.)

    Pages 1-18

  • Multiplexed Liquid Chromatography-Multiple Reaction Monitoring Mass Spectrometry Quantification of Cancer Signaling Proteins

    Chen, Yi (et al.)

    Pages 19-45

  • Monitoring Dynamic Changes of the Cell Surface Glycoproteome by Quantitative Proteomics

    Kalxdorf, Mathias (et al.)

    Pages 47-59

  • High-Resolution Parallel Reaction Monitoring with Electron Transfer Dissociation for Middle-Down Proteomics: An Application to Study the Quantitative Changes Induced by Histone Modifying Enzyme Inhibitors and Activators

    Sweredoski, Michael J. (et al.)

    Pages 61-69

  • Preparation and Immunoaffinity Depletion of Fresh Frozen Tissue Homogenates for Mass Spectrometry-Based Proteomics in the Context of Drug Target/Biomarker Discovery

    Prieto, DaRue A. (et al.)

    Pages 71-90

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-1-4939-7201-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-1-4939-7200-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-1-4939-8414-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Proteomics for Drug Discovery
Book Subtitle
Methods and Protocols
Editors
  • Iulia M. Lazar
  • Maria Kontoyianni
  • Alexandru C. Lazar
Series Title
Methods in Molecular Biology
Series Volume
1647
Copyright
2017
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media LLC
eBook ISBN
978-1-4939-7201-2
DOI
10.1007/978-1-4939-7201-2
Hardcover ISBN
978-1-4939-7200-5
Softcover ISBN
978-1-4939-8414-5
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XI, 302
Number of Illustrations
16 b/w illustrations, 46 illustrations in colour
Topics