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Methods in Molecular Biology

Proteomics for Drug Discovery

Methods and Protocols

Editors: Lazar, Iuliana M., Kontoyianni, Maria, Lazar, Alexandru C. (Eds.)

  • Includes cutting-edge techniques for the study of drug discovery via proteomics
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts
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eBook $139.00
price for USA in USD (gross)
  • ISBN 978-1-4939-7201-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-1-4939-7200-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book reflects the drug development community’s interest in proteomics methods by providing researchers with the necessary knowledge for the implementation of a number of basic experimental and bioinformatics protocols in the drug discovery research laboratory. The focus of the collection is on select protocols and methodologies that address the analysis of post-translational modifications, targeted protein quantification, protein-protein, protein-lipid, or protein-ATP interactions, in silico lead identification, protein arrays, tissue and cell extract preparation, labeling, chemoproteomics, and drug efficacy assessment. Emphasis was placed not just on methods that describe large-scale protein analysis, but also on ones that are amenable to future implementation in a high-throughput format. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 
Practical and authoritative, Proteomics for Drug Discovery: Methods and Protocols aims to provide a deep knowledge of the fundamentals of disease biology as well the means that were developed for probing the complex biological milieu.

Table of contents (20 chapters)

  • A Photoaffinity Labeling-Based Chemoproteomics Strategy for Unbiased Target Deconvolution of Small Molecule Drug Candidates

    Thomas, Jason R. (et al.)

    Pages 1-18

  • Multiplexed Liquid Chromatography-Multiple Reaction Monitoring Mass Spectrometry Quantification of Cancer Signaling Proteins

    Chen, Yi (et al.)

    Pages 19-45

  • Monitoring Dynamic Changes of the Cell Surface Glycoproteome by Quantitative Proteomics

    Kalxdorf, Mathias (et al.)

    Pages 47-59

  • High-Resolution Parallel Reaction Monitoring with Electron Transfer Dissociation for Middle-Down Proteomics: An Application to Study the Quantitative Changes Induced by Histone Modifying Enzyme Inhibitors and Activators

    Sweredoski, Michael J. (et al.)

    Pages 61-69

  • Preparation and Immunoaffinity Depletion of Fresh Frozen Tissue Homogenates for Mass Spectrometry-Based Proteomics in the Context of Drug Target/Biomarker Discovery

    Prieto, DaRue A. (et al.)

    Pages 71-90

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-1-4939-7201-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-1-4939-7200-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Proteomics for Drug Discovery
Book Subtitle
Methods and Protocols
Editors
  • Iuliana M. Lazar
  • Maria Kontoyianni
  • Alexandru C. Lazar
Series Title
Methods in Molecular Biology
Series Volume
1647
Copyright
2017
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media LLC
eBook ISBN
978-1-4939-7201-2
DOI
10.1007/978-1-4939-7201-2
Hardcover ISBN
978-1-4939-7200-5
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XI, 302
Number of Illustrations and Tables
16 b/w illustrations, 46 illustrations in colour
Topics