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Methods in Pharmacology and Toxicology

Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases

Editors: Stefanska, Barbara, MacEwan, David J. (Eds.)

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  • Explores epigenetics from the wide-angle view of epigenomics
  • Features detailed methods sections which include data analyses, troubleshooting, and feasibility in different experimental settings
  • Includes contributions from key researchers in the field
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  • ISBN 978-1-4939-6743-8
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Hardcover $159.99
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  • ISBN 978-1-4939-6741-4
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  • Immediate ebook access, if available*, with your print order
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Softcover $119.99
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  • ISBN 978-1-4939-8289-9
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About this book

This practical collection examines methodologies originating from the benefits of genome-wide approaches to studying epigenetics, which has opened the emerging field of epigenomics. Focusing on the areas of cancer, inflammatory and autoimmune disorders, chapters discuss three main components of the epigenome and their role in the regulation of gene expression and present a detailed method section specific to studying each component, including data analyses, troubleshooting, and feasibility in different experimental settings. The main topics are high-throughput and targeted methods for DNA methylation analysis, nucleosome position mapping, studying epigenetic effects of gut microbiota, optical imaging for detection of epigenetic aberrations in living cells, methods for microRNA, and histone code profiling. Written for the Methods in Pharmacology and Toxicology series, the book includes the kind of detail and implementation advice to encourage success in the lab. 
Authoritative and easily applicable, Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases aims to provide pharmacologists, molecular biologists, bioinformaticians, and toxicologists with a vital background on epigenetics and state-of-the-art techniques in epigenomics.

Table of contents (11 chapters)

Table of contents (11 chapters)
  • High-Throughput Techniques for DNA Methylation Profiling

    Pages 1-15

    Petropoulos, Sophie (et al.)

  • Reduced Representation Bisulfite Sequencing (RRBS) and Cell Sorting Prior to DNA Methylation Analysis in Psychiatric Disorders

    Pages 17-32

    Vega, Wilfred C. (et al.)

  • Targeted DNA Methylation Analysis Methods

    Pages 33-50

    Cheishvili, David (et al.)

  • Analyzing Targeted Nucleosome Position and Occupancy in Cancer, Obesity, and Diabetes

    Pages 51-62

    Devarshi, Prasad P. (et al.)

  • Synthesis and Application of Cell-Permeable Metabolites for Modulating Chromatin Modifications Regulated by α-Ketoglutarate-Dependent Enzymes

    Pages 63-79

    Balduf, Hunter T. (et al.)

Buy this book

eBook $89.00
price for USA in USD
  • ISBN 978-1-4939-6743-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-1-4939-6741-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $119.99
price for USA in USD
  • ISBN 978-1-4939-8289-9
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases
Editors
  • Barbara Stefanska
  • David J. MacEwan
Series Title
Methods in Pharmacology and Toxicology
Copyright
2017
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media LLC
eBook ISBN
978-1-4939-6743-8
DOI
10.1007/978-1-4939-6743-8
Hardcover ISBN
978-1-4939-6741-4
Softcover ISBN
978-1-4939-8289-9
Series ISSN
1557-2153
Edition Number
1
Number of Pages
XII, 197
Number of Illustrations
16 b/w illustrations, 22 illustrations in colour
Topics

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