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Methods in Pharmacology and Toxicology

Stem Cell-Derived Models in Toxicology

Editors: Clements, Mike, Roquemore, Liz (Eds.)

  • Collects stem cell-derived model-based toxicity assays, both classic and cutting-edge
    Features contributions from key opinion leaders from academia and industry
    Examines the accompanying rationale and example output data necessary for practical and easy-to-use resource

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-1-4939-6661-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA in USD
  • ISBN 978-1-4939-6659-2
  • with online files
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA in USD
  • ISBN 978-1-4939-8264-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This detailed volume brings together a diverse collection of stem cell-derived model-based toxicity assays, from those routinely used to those deemed to have considerable potential. With a focus on differentiated tissues, the chapters explore numerous cardiotoxicity applications as well as coverage of neurotoxicity, hepatotoxicity, and more. Written for the Methods in Pharmacology and Toxicology series, the contents of this book aim to enable adoption of these protocols in laboratories that are interested in entering the field as well as to facilitate the transfer of best practices between laboratories that are already actively pursuing these technologies. 
Authoritative and cutting-edge, Stem Cell-Derived Models in Toxicology serves as a vital resource for researchers aiming to improve risk assessment in drug discovery and design.

Table of contents (16 chapters)

  • Stem Cell-Derived Models for Safety and Toxicity Assessments: Present and Future Studies in the “Proclinical Space”

    Gintant, Gary (et al.)

    Pages 1-15

  • Human Pluripotent Stem Cell Test for Assessing the Potential Teratogen Risk

    Kameoka, Sei (et al.)

    Pages 17-35

  • Cardiac Action Potential Measurement in Human Embryonic Stem Cell Cardiomyocytes for Cardiac Safety Studies Using Manual Patch-Clamp Electrophysiology

    Renganathan, Muthukrishnan (et al.)

    Pages 37-56

  • Automated Patch Clamp Recordings of Human Stem Cell-Derived Cardiomyocytes

    Obergrussberger, Alison (et al.)

    Pages 57-82

  • The CiPA Microelectrode Array Assay with hSC-Derived Cardiomyocytes: Current Protocol, Future Potential

    Millard, Daniel C. (et al.)

    Pages 83-107

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-1-4939-6661-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA in USD
  • ISBN 978-1-4939-6659-2
  • with online files
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA in USD
  • ISBN 978-1-4939-8264-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Stem Cell-Derived Models in Toxicology
Editors
  • Mike Clements
  • Liz Roquemore
Series Title
Methods in Pharmacology and Toxicology
Copyright
2017
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-4939-6661-5
DOI
10.1007/978-1-4939-6661-5
Hardcover ISBN
978-1-4939-6659-2
Softcover ISBN
978-1-4939-8264-6
Series ISSN
1557-2153
Edition Number
1
Number of Pages
XII, 341
Number of Illustrations
16 b/w illustrations, 108 illustrations in colour
Topics