Methods in Molecular Biology

HDAC/HAT Function Assessment and Inhibitor Development

Methods and Protocols

Editors: Krämer, Oliver H. (Ed.)

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  • Includes cutting-edge methods and protocols to study HDACs and HATs
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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  • ISBN 978-1-4939-6527-4
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Hardcover $169.99
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Softcover $139.00
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  • ISBN 978-1-4939-8226-4
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About this book

This detailed collection covers how the biological functions of histone deacetylases (HDACs) and histone acetyltransferases (HATs) can be detected in various experimental settings, both in vivo and in vitro. The book also covers the generation and specificity of deacetylase inhibitors and how such agents can be used to test experimental hypotheses. Written for the popular Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls.
Comprehensive and practical, HDAC/HAT Function Assessment and Inhibitor Development: Methods and Protocols serves as an ideal guide to this vital area of study.

Table of contents (31 chapters)

Table of contents (31 chapters)
  • Detection of Autophagy Induction After HDAC Inhibitor Treatment in Leukemic Cells

    Pages 3-10

    Göder, Anja (et al.)

  • Assessment of HDACi-Induced Protein Cleavage by Caspases

    Pages 11-22

    Treude, Fabian (et al.)

  • Assessment of HDACi-Induced Cytotoxicity

    Pages 23-45

    Marx-Blümel, Lisa (et al.)

  • Analysis of HDACi-Induced Changes in Chromosomal Passenger Complex Localization

    Pages 47-59

    Unruhe-Knauf, Britta (et al.)

  • Analysis of Histone Deacetylase-Dependent Effects on Cell Migration Using the Stripe Assay

    Pages 61-75

    Mertsch, Sonja (et al.)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-1-4939-6527-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-1-4939-6525-0
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $139.00
price for USA in USD
  • ISBN 978-1-4939-8226-4
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
HDAC/HAT Function Assessment and Inhibitor Development
Book Subtitle
Methods and Protocols
Editors
  • Oliver H. Krämer
Series Title
Methods in Molecular Biology
Series Volume
1510
Copyright
2017
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-6527-4
DOI
10.1007/978-1-4939-6527-4
Hardcover ISBN
978-1-4939-6525-0
Softcover ISBN
978-1-4939-8226-4
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XIV, 415
Number of Illustrations
39 b/w illustrations, 58 illustrations in colour
Topics