Antiepileptic Drug Discovery

1. Front Matter

   Pages i-xi

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2. Novel Approaches for the Treatment of Epilepsy

   1. Front Matter

      Pages 1-1

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   2. Inflammatory Cytokines as Targets for Epilepsy Drug Therapy

      • María-Leonor López-Meraz, Jesús-Servando Medel-Matus, Jerome Niquet

      Pages 3-22

   3. The Use of Anti-inflammatory Drugs in Epilepsy

      • María Guadalupe Valle-Dorado, Laura Elena Córdova-Dávalos, Daniel Pérez-Pérez, Rosalinda Guevara-Guzmán, Luisa Rocha

      Pages 23-36

   4. Carbonic Anhydrase and Epilepsy

      • Luciana Gavernet

      Pages 37-51

   5. Synaptic Vesicle Protein 2A as a Novel Pharmacological Target with Broad Potential for New Antiepileptic Drugs

      • Luz Adriana Pichardo-Macías, Itzel Jatziri Contreras-García, Sergio R. Zamudio, Edgar Mixcoha, Julieta G. Mendoza-Torreblanca

      Pages 53-81

   6. Do Cannabinoids Represent a Good Therapeutic Strategy for Epilepsy?

      • Cecilia Zavala-Tecuapetla, Luisa Rocha

      Pages 83-96

   7. Glutamate Receptors as Targets for Novel Antiepileptic Drug Therapy

      • Manola Cuéllar-Herrera, César E. Santana-Gómez, Francia Carmona-Cruz, Daruni Vázquez-Barrón, Francisco Velasco, Ana L. Velasco

      Pages 97-125

   8. Neurosteroid Regulation of Seizures: Role of GABAA Receptor Plasticity

      • Suchitra Joshi, Jaideep Kapur

      Pages 127-146

   9. Erythropoietin as Potential Neuroprotective and Antiepileptogenic Agent in Epilepsy and Refractory Epilepsy

      • Amalia Marelli, Liliana Czornyj, Luisa Rocha, Alberto Lazarowski

      Pages 147-161

   10. Caloric Restriction and Dietary Treatments of Epilepsy: Mechanistic Insights for Drug Discovery

       • Karla G. Carvajal Aguilera, Bryan V. Phillips Farfán

       Pages 163-180

   11. Gene Therapy in Epilepsy

       • Miguel A. López-García, Iris A. Feria-Romero, Julia J. Segura-Uribe, David Escalante-Santiago, Sandra Orozco-Suárez

       Pages 181-200

3. Innovative Solutions for the Screening of New Antiepileptics Drugs and Addressing Multi-Drug Resistant Epilepsy

   1. Front Matter

      Pages 201-201

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   2. Human Brain Tissue as a Model for the Study of Epilepsy

      • Leonardo Lara-Valderrábano, Ivette Bañuelos-Cabrera, Víctor Navarrete-Modesto, Luisa Rocha

      Pages 203-219

   3. The Blood–Brain Barrier and the Design of New Antiepileptic Drugs

      • Gabriela Rogel-Salazar, Hiram Luna-Munguia

      Pages 221-236

   4. Virtual Screening Applications in the Search of Novel Antiepileptic Drug Candidates

      • Alan Talevi, Luis E. Bruno-Blanch

      Pages 237-258

   5. Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Ligand-Based Approximations

      • Manuel Couyoupetrou, Mauricio Di Ianni, Melisa Gantner, Guido Pesce, Roxana Peroni, Alan Talevi et al.

      Pages 259-279

   6. Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Structure-Based Approximations

      • Pablo Palestro, Luciana Gavernet

      Pages 281-297

   7. Nanoformulations of Antiepileptic Drugs: In Vitro and In Vivo Studies

      • María E. Ruiz, Guillermo R. Castro

      Pages 299-326

4. Potential Contributions of Network Pharmacology and Drug Repurposing in Antiepileptic Drug Discovery

   1. Front Matter

      Pages 327-327

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This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory. 

Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and the discovery of new antiepileptic drugs.

• Antiepileptogenesis
• Epilepsy treatment
• Multi-drug resistance
• Network Pharmacology
• Drug repurposing
• Pharmaceutical screening
• Computer-aided approaches

• Laboratorio de Investigación y Desarrollo de Bioactivos (LIDeB) Faculty of Exact Sciences, National University of La Plata, La Plata, Argentina

  Alan Talevi

• Department of Pharmacobiology, Center for Research and Advanced Studies, Mexico City, Mexico

  Luisa Rocha

Policies and ethics