Methods in Molecular Biology

High-Throughput Screening Assays in Toxicology

Editors: Zhu, Hao, Xia, Menghang (Eds.)

  • Includes cutting-edge methods and protocols for HTS assays to examine toxicity
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
see more benefits

Buy this book

eBook $89.00
price for USA in USD (gross)
  • ISBN 978-1-4939-6346-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $119.00
price for USA in USD
  • ISBN 978-1-4939-6344-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book focuses on recently developed High Throughput Screening (HTS) assay protocols, many involved in the ToxCast and/or Tox21 initiatives, and the relevant HTS data analysis techniques. Divided into three sections, in vitro assays, in vivo assays, and computational techniques to analyze HTS data are all examined. Written for the highly successful Methods in Molecular Biology series, most chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 
Authoritative and practical, High Throughput Screening Assays in Toxicology serves as a valuable reference resource for translating new HTS techniques into standardized chemical toxicity assessment tools in order to advance modern toxicology research to a new era where HTS techniques can partially replace the prevailing animal models.

Table of contents (17 chapters)

  • Monitoring Ligand-Activated Protein–Protein Interactions Using Bioluminescent Resonance Energy Transfer (BRET) Assay

    Coriano, Carlos (et al.)

    Pages 3-15

  • Mitochondrial Membrane Potential Assay

    Sakamuru, Srilatha (et al.)

    Pages 17-22

  • Using β-Lactamase and NanoLuc Luciferase Reporter Gene Assays to Identify Inhibitors of the HIF-1 Signaling Pathway

    Khuc, Thai (et al.)

    Pages 23-31

  • Quantitative High-Throughput Luciferase Screening in Identifying CAR Modulators

    Lynch, Caitlin (et al.)

    Pages 33-42

  • Transactivation and Coactivator Recruitment Assays for Measuring Farnesoid X Receptor Activity

    Hsu, Chia-Wen (Amy) (et al.)

    Pages 43-53

Buy this book

eBook $89.00
price for USA in USD (gross)
  • ISBN 978-1-4939-6346-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $119.00
price for USA in USD
  • ISBN 978-1-4939-6344-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
High-Throughput Screening Assays in Toxicology
Editors
  • Hao Zhu
  • Menghang Xia
Series Title
Methods in Molecular Biology
Series Volume
1473
Copyright
2016
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-6346-1
DOI
10.1007/978-1-4939-6346-1
Hardcover ISBN
978-1-4939-6344-7
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XII, 175
Number of Illustrations and Tables
18 b/w illustrations, 32 illustrations in colour
Topics