Methods in Molecular Biology

Computational Design of Ligand Binding Proteins

Editors: Stoddard, Barry L. (Ed.)

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  • Includes cutting-edge methods and protocols
  • Provide step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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  • ISBN 978-1-4939-3569-7
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About this book

This volume provides a collection of protocols and approaches for the creation of novel ligand binding proteins, compiled and described by many of today's leaders in the field of protein engineering. Chapters focus on modeling protein ligand binding sites, accurate modeling of protein-ligand conformational sampling, scoring of individual docked solutions, structure-based design program such as ROSETTA, protein engineering, and additional methodological approaches. Examples of applications include the design of metal-binding proteins and light-induced ligand binding proteins, the creation of binding proteins that also display catalytic activity, and the binding of larger peptide, protein, DNA and RNA ligands. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.


Table of contents (21 chapters)

Table of contents (21 chapters)
  • In silico Identification and Characterization of Protein-Ligand Binding Sites

    Pages 1-21

    Roche, Daniel Barry (et al.)

  • Computational Modeling of Small Molecule Ligand Binding Interactions and Affinities

    Pages 23-32

    Convertino, Marino (et al.)

  • Binding Site Prediction of Proteins with Organic Compounds or Peptides Using GALAXY Web Servers

    Pages 33-45

    Heo, Lim (et al.)

  • Rosetta and the Design of Ligand Binding Sites

    Pages 47-62

    Moretti, Rocco (et al.)

  • PocketOptimizer and the Design of Ligand Binding Sites

    Pages 63-75

    Stiel, Andre C. (et al.)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-1-4939-3569-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Hardcover $179.99
price for USA in USD
Softcover $139.00
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Computational Design of Ligand Binding Proteins
Editors
  • Barry L. Stoddard
Series Title
Methods in Molecular Biology
Series Volume
1414
Copyright
2016
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-3569-7
DOI
10.1007/978-1-4939-3569-7
Hardcover ISBN
978-1-4939-3567-3
Softcover ISBN
978-1-4939-8080-2
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XVI, 375
Number of Illustrations
18 b/w illustrations, 76 illustrations in colour
Topics