Ion Channels and Transporters of Epithelia in Health and Disease

1. Front Matter

   Pages i-xiv

   PDF

2. Basic Epithelial Ion Transport Principles and Function

   1. Front Matter

      Pages 1-1

      PDF

   2. Fundamentals of Epithelial Cl− Transport

      • Bruce D. Schultz, Daniel C. Devor

      Pages 3-47

   3. Fundamentals of Epithelial Na+ Absorption

      • Alexander Staruschenko, Daria V. Ilatovskaya, Kenneth R. Hallows

      Pages 49-94

   4. Physiologic Influences of Transepithelial K+ Secretion

      • Dan R. Halm

      Pages 95-130

   5. Volume Regulation in Epithelia

      • Erik Hviid Larsen, Else Kay Hoffmann

      Pages 131-185

   6. Fundamentals of Bicarbonate Secretion in Epithelia

      • Ivana Novak, Jeppe Praetorius

      Pages 187-263

   7. Mathematical Modeling of Epithelial Ion Transport

      • David P. Nickerson, Kirk L. Hamilton, Peter J. Hunter

      Pages 265-278

   8. Molecular Mechanisms of Apical and Basolateral Sorting in Polarized Epithelial Cells

      • Ora A. Weisz, Heike Fölsch

      Pages 279-302

   9. Membrane Protein Folding and Structure

      • Liang Zhang, Patrick H. Thibodeau

      Pages 303-331

3. Epithelial Ion Channels and Transporters

   1. Front Matter

      Pages 333-333

      PDF

   2. P2X Receptors in Epithelia

      • Jens Leipziger

      Pages 335-350

   3. Na+/K+-ATPase Drives Most Asymmetric Transports and Modulates the Phenotype of Epithelial Cells

      • Marcelino Cereijido, Isabel Larre, Omar Paez, Liora Shoshani, Arturo Ponce

      Pages 351-374

   4. Na+-K+-2Cl− Cotransporter

      • Eric Delpire, Kenneth B. Gagnon

      Pages 375-400

   5. Thiazide-Sensitive NaCl Cotransporter

      • Arohan R. Subramanya

      Pages 401-435

   6. NBCe1, an Electrogenic Na+ Bicarbonate Cotransporter, in Epithelia

      • Aleksandra Sinđić, Michael F. Romero

      Pages 437-463

   7. Properties and Function of the Solute Carrier 26 Family of Anion Transporters

      • Nikolay Shcheynikov, Ehud Ohana, Shmuel Muallem

      Pages 465-489

   8. ClC-2 Chloride Channels

      • John Cuppoletti, Danuta H. Malinowska, Ryuji Ueno

      Pages 491-518

   9. CFTR and Cystic Fibrosis

      • William T. Harris, Kevin L. Kirk

      Pages 519-552

   10. TMEM16 Proteins (Anoctamins) in Epithelia

       • Paolo Scudieri, Luis J. V. Galietta

       Pages 553-567

This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels. 

• Epithelial ion transport
• Transepithelial secretion
• Potassium channels
• Sodium channels and absorption
• Chloride channels and transport
• Bicarbonate secretion
• Membrane protein folding and structure
• Kidney transport processes
• Maintaining homeostasis
• Cystic fibrosis
• Receptors

• Department of Physiology, University of Otago , Dunedin, New Zealand

  Kirk L. Hamilton

• Department of Cell Biology, University of Pittsburgh, Pittsburgh, USA

  Daniel C Devor

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