Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells

Novel Insights into Disease Mechanisms

Editors: Nickerson, Cheryl A., Pellis, Neal R., Ott, C. Mark (Eds.)

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  • 2017 winner of the International Academy of Astronautics Life Science Book Award
  • Offers a new perspective on the architecture and physiology of all biological systems
  • Explores fundamental questions about human health in a microgravity environment
  • Addresses a subject that has not been covered comprehensively in any published volume
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  • ISBN 978-1-4939-3277-1
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Hardcover $199.99
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Softcover $199.99
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About this book

Many breakthroughs in biological research and translational healthcare advancements have been achieved by studying the response of biological systems to extreme environments. The spaceflight platform provides a unique environment where researchers can explore fundamental questions into cellular and molecular response mechanisms to unveil novel insight into human health and disease.  Since the physical force of gravity has shaped the architecture of all biological systems on our planet, spaceflight provides the opportunity to see life in a new adaptational mode - in response to reduced gravity. This enables investigations into the effects of the microgravity environment and associated changes in mechanical forces on mammalian cells/tissues and microbial pathogens, to bring novel insight into disease mechanisms, which are not discernable using conventional experimental approaches.

Research using spaceflight platforms represents a paradigm shift in how we observe life processes and is on the leading edge of research discoveries into cellular and molecular mechanisms of health and disease. By incorporating the views of leading authors, this book highlights landmark discoveries and advances in mammalian cellular and microbiology research in both true spaceflight and ground-based spaceflight analogue environments for scientists and students alike who are interested in the influence of physical forces on mammalian and microbial cells, how this impacts transition between normal homeostasis and disease, and basic mechanisms of adaptation to low gravity environments.  To provide a thorough understanding of this research, this book covers a range of topics including:

(i) description the physical forces interacting with cells in microgravity and microgravity analogue environments,

(ii) how alterations in these cellular forces impact human physiology, specifically immune function,

(iii) use of these environments to develop organotypic three-dimensional (3-D) tissue culture models as predictive human surrogates for organogenesis and disease research, and

(iv) microbial pathogen responses to culture in these environments, focusing on infectious disease 

Collectively, this information reflects a critical step in preparation for long-duration human space exploration, advances our knowledge of basic biological processes and mechanisms important to understand normal function and disease, and may lead to new strategies for treatment and prevention. 

About the authors

Cheryl A. Nickerson, School of Life Sciences, The Biodesign Institute, Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ, USA
Neal R. Pellis, Division of Space Life Science, Universities Space Research Association, Houston, TX, USA
C. Mark Ott, Biomedical Research and Environmental, Sciences Division, NASA/Johnson Space Center, Houston, TX, USA









Table of contents (14 chapters)

Table of contents (14 chapters)
  • Overview and Translational Impact of Space Cell Biology Research

    Pages 3-37

    Pellis, Neal R. (et al.)

  • Principles of Analogue and True Microgravity Bioreactors to Tissue Engineering

    Pages 39-60

    Wolf, David A. (et al.)

  • Immune Dysfunction in Spaceflight: An Integrative View

    Pages 61-79

    Yi, Buqing (et al.)

  • Biomedical Advances in Three Dimensions: An Overview of Human Cellular Studies in Space and Spaceflight Analogues

    Pages 83-92

    Nickerson, Cheryl A., PhD (et al.)

  • Outpacing Infectious Disease: Mimicking the Host-Pathogen Microenvironment in Three-Dimensions

    Pages 93-119

    Crabbé, Aurélie (et al.)

Buy this book

eBook $149.00
price for USA in USD
  • ISBN 978-1-4939-3277-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Hardcover $199.99
price for USA in USD
Softcover $199.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells
Book Subtitle
Novel Insights into Disease Mechanisms
Editors
  • Cheryl A. Nickerson
  • Neal R. Pellis
  • C. Mark Ott
Copyright
2016
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-3277-1
DOI
10.1007/978-1-4939-3277-1
Hardcover ISBN
978-1-4939-3276-4
Softcover ISBN
978-1-4939-8010-9
Edition Number
1
Number of Pages
XVIII, 301
Number of Illustrations
21 b/w illustrations, 45 illustrations in colour
Topics