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Methods in Molecular Biology

Gene Therapy for Neurological Disorders

Methods and Protocols

Editors: Manfredsson, Fredric P. (Ed.)

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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eBook $139.00
price for USA in USD
  • ISBN 978-1-4939-3271-9
  • Digitally watermarked, DRM-free
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  • Immediate eBook download after purchase Institutional customers should get in touch with their account manager
Hardcover $249.99
price for USA in USD
Softcover $179.00
price for USA in USD
About this book

This volume provides a clear and detailed roadmap of how to design and execute a gene therapy experiment in order to obtain consistent results. Chapters in this book disseminate bits of unknown information that are important to consider during the course of experimentation and will answer questions such as: What delivery vehicle do you use?; How will you ensure that your vector retains stability?; What expression system best fits your needs?; What route will you choose to deliver your gene therapy agent?; How will you model the neurodegenerative disorder that you aim to investigate and what are the proven methods to treat these disorders in preclinical models? Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.

Authoritative and thorough, Gene Therapy for Neurological Disorders: Methods and Protocols, is a compilation of protocols and instructive chapters intended to give researchers, clinicians, and students of all levels, a foundation upon which future gene therapy experiments can be designed.

About the authors

Fredric P. Manfredsson, Ph.D. Assistant Professor Michigan State University Division of Translational Science & Molecular Medicine Van Andel Institute 333 Bostwick Ave NE Grand Rapids, MI 49503 Tel: 616-234-0968 Fax: 616-234-0990

Table of contents (32 chapters)

Table of contents (32 chapters)
  • Introduction to Viral Vectors and Other Delivery Methods for Gene Therapy of the Nervous System

    Pages 3-18

    Manfredsson, Fredric P., Ph.D.

  • Delivering Transgenic DNA Exceeding the Carrying Capacity of AAV Vectors

    Pages 21-39

    Hirsch, Matthew L. (et al.)

  • Expression of Multiple Functional RNAs or Proteins from One Viral Vector

    Pages 41-56

    Björklund, Tomas

  • Regulated Gene Therapy

    Pages 57-66

    Breger, Ludivine (et al.)

  • Design of shRNA and miRNA for Delivery to the CNS

    Pages 67-80

    Toro Cabrera, Gabriela (et al.)

Buy this book

eBook $139.00
price for USA in USD
  • ISBN 978-1-4939-3271-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase Institutional customers should get in touch with their account manager
Hardcover $249.99
price for USA in USD
Softcover $179.00
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Gene Therapy for Neurological Disorders
Book Subtitle
Methods and Protocols
Editors
  • Fredric P. Manfredsson
Series Title
Methods in Molecular Biology
Series Volume
1382
Copyright
2016
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-3271-9
DOI
10.1007/978-1-4939-3271-9
Hardcover ISBN
978-1-4939-3270-2
Softcover ISBN
978-1-4939-4896-3
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XIV, 493
Topics