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Methods in Molecular Biology

Mitochondrial DNA

Methods and Protocols

Editors: McKenzie, Matthew (Ed.)

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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  • ISBN 978-1-4939-3040-1
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Hardcover $169.99
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Softcover $119.99
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About this book

This third edition is comprised of well-established protocols that are considered the gold standard in the field as well as new methodologies for mitochondrial DNA analysis. of Mitochondrial DNA: Methods and Protocols describes protocols for detecting mutations in mitochondrial DNA, techniques to assess mitochondrial DNA damage, visualization of mitochondrial DNA in situ, detection of mitochondrial DNA nucleoids within the mitochondria, methods for analyzing mitochondrial DNA replication, mitochondrial DNA-encoded protein translation and  mitochondrial DNA copy number,  the latest technologies for modifying the mitochondrial genome and methods for the purification of proteins involved in the replication and transcription of mitochondrial DNA. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Mitochondrial DNA: Methods and Protocols, Third Edition will be useful not only for mitochondrial researchers but also for scientists studying human diseases where mitochondrial DNA variation has been recognized as an important pathogenic factor, including cancer and neurodegeneration.

Table of contents (18 chapters)

Table of contents (18 chapters)
  • Comprehensive Mitochondrial Genome Analysis by Massively Parallel Sequencing

    Pages 3-17

    Palculict, Meagan E. (et al.)

  • Analysis of Translesion DNA Synthesis by the Mitochondrial DNA Polymerase γ

    Pages 19-26

    Copeland, William C. (et al.)

  • Quantification of DNA Damage by Real-Time qPCR

    Pages 27-32

    Wang, Wei (et al.)

  • Quantitation of Mitochondrial DNA Deletions Via Restriction Digestion/Long-Range Single-Molecule PCR

    Pages 33-46

    Kraytsberg, Yevgenya (et al.)

  • A Single-Cell Resolution Imaging Protocol of Mitochondrial DNA Dynamics in Physiopathology, mTRIP, Which Also Evaluates Sublethal Cytotoxicity

    Pages 49-65

    Chatre, Laurent (et al.)

Buy this book

eBook $89.00
price for USA in USD (gross)
  • ISBN 978-1-4939-3040-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-1-4939-3039-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $119.99
price for USA in USD
  • ISBN 978-1-4939-4944-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mitochondrial DNA
Book Subtitle
Methods and Protocols
Editors
  • Matthew McKenzie
Series Title
Methods in Molecular Biology
Series Volume
1351
Copyright
2016
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-3040-1
DOI
10.1007/978-1-4939-3040-1
Hardcover ISBN
978-1-4939-3039-5
Softcover ISBN
978-1-4939-4944-1
Series ISSN
1064-3745
Edition Number
3
Number of Pages
XI, 234
Topics