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Methods in Molecular Biology

TGF-β Signaling

Methods and Protocols

Editors: Feng, Xin-Hua, Xu, Pinglong, Lin, Xia (Eds.)

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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eBook $109.00
price for USA in USD (gross)
  • ISBN 978-1-4939-2966-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-1-4939-2965-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA in USD
  • ISBN 978-1-4939-4993-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume details up-to-date information and attempts to take the reader into the exciting realm of TGF-β from the basic principles to the practical applications. Chapters provide basic introduction of TGF-β signaling from the cell surface to the nucleus, methods and techniques for the investigation of TGF-β signaling mechanism including receptors, Smads, intracellular kinases, microRNA, epigenetic regulation, post-translational regulations, non-Smad pathway; the physiological implications including those in cell cycle arrest, epithelial-mesenchymal transition, endothelial cells, adipogenesis, Th differentiation, stem cell, bone remodeling, ovary, zebrofish development, and frog animal capping; and the methodologies including metastasis imaging, 3D morphogenesis, membrane receptor quantification, conditional knockout, bone remodeling, kinase and phosphatase assays, BiFC interaction assays, and genome-wide siRNA screen. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

 

Authoritative and practical, TGF-Beta Signaling: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Table of contents (25 chapters)

  • Regulation of TGF-β Receptors

    Budi, Erine H. (et al.)

    Pages 1-33

  • Determining TGF-β Receptor Levels in the Cell Membrane

    Zhang, Long (et al.)

    Pages 35-47

  • Posttranslational Modifications of TGF-β Receptors

    Yan, Xiaohua (et al.)

    Pages 49-61

  • Production, Isolation, and Structural Analysis of Ligands and Receptors of the TGF-β Superfamily

    Huang, Tao (et al.)

    Pages 63-92

  • Phosphorylation of Smads by Intracellular Kinases

    Liu, Fang (et al.)

    Pages 93-109

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-1-4939-2966-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-1-4939-2965-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA in USD
  • ISBN 978-1-4939-4993-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
TGF-β Signaling
Book Subtitle
Methods and Protocols
Editors
  • Xin-Hua Feng
  • Pinglong Xu
  • Xia Lin
Series Title
Methods in Molecular Biology
Series Volume
1344
Copyright
2016
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-2966-5
DOI
10.1007/978-1-4939-2966-5
Hardcover ISBN
978-1-4939-2965-8
Softcover ISBN
978-1-4939-4993-9
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XII, 394
Topics