G Protein-Coupled Receptors in Drug Discovery
Methods and Protocols
Editors: Filizola, Marta (Ed.)
- Includes cutting-edge methods and protocols on GPCRs in drug discovery
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
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- About this book
-
This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.
Practical and fully updated, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, Second Edition serves as an ideal guide for a diverse audience from structural and molecular biologists to pharmacologists and drug designers who wish to explore this extensive class of key drug targets.
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Bibliographic Information
- Bibliographic Information
-
- Book Title
- G Protein-Coupled Receptors in Drug Discovery
- Book Subtitle
- Methods and Protocols
- Editors
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- Marta Filizola
- Series Title
- Methods in Molecular Biology
- Series Volume
- 1335
- Copyright
- 2015
- Publisher
- Humana Press
- Copyright Holder
- Springer Science+Business Media New York
- eBook ISBN
- 978-1-4939-2914-6
- DOI
- 10.1007/978-1-4939-2914-6
- Hardcover ISBN
- 978-1-4939-2913-9
- Softcover ISBN
- 978-1-4939-4967-0
- Series ISSN
- 1064-3745
- Edition Number
- 2
- Number of Pages
- XII, 327
- Number of Illustrations and Tables
- 21 b/w illustrations, 50 illustrations in colour
- Topics
