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Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development

  • Book
  • © 2015

Overview

Editors:
  1. Steven J. Potts

    1. Flagship Biosciences, LLC, Westminster, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. David A. Eberhard

    1. University of North Carolina, Chapel Hill, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Keith A. Wharton, Jr.

    1. Novartis Institutes for BioMedical Research, Cambridge, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Explores pathology in oncologic disease and beyond, into other disease areas that have not received as much attention
  • Provides practical wisdom and examples from histopathology experts to apply to drug development programs
  • Features techniques, case studies, reviews, and collections of the authors' experiences in the field

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

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Table of contents (24 protocols)

  1. Front Matter

    Pages i-xviii
    Download chapter PDF

  2. Histopathology: A Canvas and Landscape of Disease in Drug and Diagnostic Development

    • Keith A. Wharton Jr.
    Pages 1-26

  3. A Field Guide to Homo morphologicus for Biomedical Scientists, Or How to Convey an Understanding of Pathology to Scientists in a Biopharma Enterprise

    • Humphrey Gardner
    Pages 27-41

  4. Outsourcing Tissue Histopathology Investigations in Support of Clinical Trials for Novel Therapeutics: Considerations and Perspectives

    • Keith A. Wharton Jr., Benjamin H. Lee, Pierre Moulin, Dale Mongeon, Rainer Hillenbrand, Arkady Gusev et al.
    Pages 43-63

  5. Histopathology in Mouse Models of Rheumatoid Arthritis

    • Patrick Caplazi, Lauri Diehl
    Pages 65-78

  6. Markers Used for Visualization and Quantification of Blood and Lymphatic Vessels

    • Mohamed E. Salama, David A. Eberhard, Steven J. Potts
    Pages 79-85

  7. Practical Approaches to Microvessel Analysis: Hotspots, Microvessel Density, and Vessel Proximity

    • Steven J. Potts, David A. Eberhard, Mohamed E. Salama
    Pages 87-100

  8. Quantitative Histopathology and Alternative Approaches to Assessment of Fibrosis for Drug Development in Hepatitis C and Nonalcoholic Steatohepatitis

    • Steven J. Potts, Johanna K. DiStefano
    Pages 101-116

  9. Stereology and Computer-Based Image Analysis Quantifies Heterogeneity and Improves Reproducibility for Grading Reticulin in Myeloproliferative Neoplasms

    • Mohamed E. Salama, Erik Hagendorn, Sherrie L. Perkins, Jeff L. Kutok, A. Etman, Josef T. Prchal et al.
    Pages 117-126

  10. Image Analysis Tools for Quantification of Spinal Motor Neuron Subtype Identities

    • Mirza Peljto, Hynek Wichterle
    Pages 127-139

  11. Development of a Tissue Image Analysis Algorithm for Celiac Drug Development

    • Erik Hagendorn, Christa Whitney-Miller, Aaron Huber, Steven J. Potts
    Pages 141-152

  12. Quantitative Histopathology for Evaluation of In Vivo Biocompatibility Associated with Biomedical Implants

    • Robert B. Diller, Robert G. Audet, Robert S. Kellar
    Pages 153-162

  13. Quantitative Histomorphometry and Quantitative Polymerase Chain Reaction (PCR) as Assessment Tools for Product Development

    • Robert G. Audet, Robert B. Diller, Robert S. Kellar
    Pages 163-174

  14. Measuring the Messenger: RNA Histology in Formalin-Fixed Tissues

    • Steven J. Potts, Mirza Peljto, Mahipal Suraneni, Joseph S. Krueger
    Pages 175-182

  15. Algorithm-Driven Image Analysis Solutions for RNA ISH Quantification in Human Clinical Tissues

    • Mirza Peljto, Joseph S. Krueger, Nicholas D. Landis, G. David Young, Steven J. Potts, Holger Lange
    Pages 183-189

  16. Solid Tissue-Based DNA Analysis by FISH in Research and Molecular Diagnostics

    • Marcus Otte
    Pages 191-202

  17. Preanalytic Considerations for Molecular Genomic Analyses of Tissue

    • Maureen Cronin
    Pages 203-217

  18. Next-Generation Sequencing (NGS) in Anatomic Pathology Discovery and Practice

    • Matthew J. McGinniss, David A. Eberhard, Keith A. Wharton Jr.
    Pages 219-257

  19. The Impact of Pre-analytic Variables on Tissue Quality from Clinical Samples Collected in a Routine Clinical Setting: Implications for Diagnostic Evaluation, Drug Discovery, and Translational Research

    • David G. Hicks
    Pages 259-270

  20. Adapting HER2 Testing for a Different Organ: New Wine in Old Wineskins

    • Michael D. Lunt, Christa L. Whitney-Miller
    Pages 271-279
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Keywords

About this book

Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development gathers diverse experts to present state of the art guidance and application of histopathology in drug development settings ranging from discovery research to human clinical trials. While many current applications of quantitative histology and molecular pathology in the biopharmaceutical industry are focused on oncology, this volume in addition explores non-oncologic disease areas including nonalcoholic steatohepatitis, arthritis, celiac disease, myeloproliferative disorders, neurology, and wound healing. The authors write from years of experience in diagnostic practice and pharmaceutical drug development, aiming to educate pharmaceutical and academic scientists how to best use tissue to diagnose disease and improve the process of drug development.  As part of the Methods in Pharmacology and Toxicology series, this volume is designed to provide wisdom and examples that others can follow and apply as part of drug development.

Comprehensive and practical, Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development will inform and enlighten both tissue-focused and non-tissue-focused drug development professionals about better use and interpretation of the multidimensional data contained in a tissue biopsy.

Editors and Affiliations

  • Flagship Biosciences, LLC, Westminster, USA

    Steven J. Potts

  • University of North Carolina, Chapel Hill, USA

    David A. Eberhard

  • Novartis Institutes for BioMedical Research, Cambridge, USA

    Keith A. Wharton, Jr.

Bibliographic Information

  • Book Title: Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development

  • Editors: Steven J. Potts, David A. Eberhard, Keith A. Wharton, Jr.

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-4939-2681-7

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2015

  • Hardcover ISBN: 978-1-4939-2680-0Published: 15 June 2015

  • Softcover ISBN: 978-1-4939-5420-9Published: 29 October 2016

  • eBook ISBN: 978-1-4939-2681-7Published: 15 June 2015

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: XVIII, 375

  • Number of Illustrations: 20 b/w illustrations, 37 illustrations in colour

  • Topics: Pharmacology/Toxicology

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