Advances in Experimental Medicine and Biology

Cell Signaling During Mammalian Early Embryo Development

Editors: Leese, Henry J., Brison, Daniel R. (Eds.)

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  • Edited by two leaders in the field of reproductive biology
  • One of the first books on cell signaling in early embryo development
  • Covers signaling events from the zygote embryo through to the blastocyst
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  • ISBN 978-1-4939-2480-6
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Hardcover $179.99
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  • ISBN 978-1-4939-2479-0
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Softcover $159.99
price for USA in USD
  • ISBN 978-1-4939-4828-4
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  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
About this book

The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research.

About the authors

Henry Leese, PhD, is a Professor of Biology at Hull York Medical School and the founding Editor-in-Chief of Human Fertility. Daniel  Brison, PhD, is Honorary Professor of Clinical Embryology and Stem Cell Biology; Scientific Director of the Department of Reproductive Medicine; and Co-Director NW Embryonic Stem Cell Centre (NWESCC) at Central Manchester University Hospitals NHS Foundation Trust at St. Mary’s Hospital.

Table of contents (7 chapters)

Table of contents (7 chapters)
  • Cell Signalling During Blastocyst Morphogenesis

    Pages 1-21

    Eckert, Judith J. (et al.)

  • Amino Acids and Conceptus Development During the Peri-Implantation Period of Pregnancy

    Pages 23-52

    Bazer, Fuller W. (et al.)

  • The Role of Hexosamine Biosynthesis and Signaling in Early Development

    Pages 53-76

    Pantaleon, Dr. Marie, Bsc (Hons IA) PhD

  • Molecular Biology of the Stress Response in the Early Embryo and its Stem Cells

    Pages 77-128

    Puscheck, Elizabeth E. (et al.)

  • Survival Signalling in the Preimplantation Embryo

    Pages 129-149

    O’Neill, C. (et al.)

Buy this book

eBook $119.00
price for USA in USD
  • ISBN 978-1-4939-2480-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-1-4939-2479-0
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $159.99
price for USA in USD
  • ISBN 978-1-4939-4828-4
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Cell Signaling During Mammalian Early Embryo Development
Editors
  • Henry J. Leese
  • Daniel R. Brison
Series Title
Advances in Experimental Medicine and Biology
Series Volume
843
Copyright
2015
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-2480-6
DOI
10.1007/978-1-4939-2480-6
Hardcover ISBN
978-1-4939-2479-0
Softcover ISBN
978-1-4939-4828-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XII, 216
Number of Illustrations
5 b/w illustrations, 16 illustrations in colour
Topics