Mitochondrial Medicine
Volume I, Probing Mitochondrial Function
Editors: Weissig, Volkmar, Edeas, Marvin (Eds.)
Free Preview- Includes cutting-edge methods and protocols for the assessment of mitochondrial function
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
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- About this book
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This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. Mitochondrial Medicine: Volume I, Probing Mitochondrial Function focuses on methods being used for the assessment of mitochondrial function under physiological conditions as well as in healthy isolated mitochondria. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and practical, Mitochondrial Medicine provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.
- Table of contents (38 chapters)
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Preparation of “Functional” Mitochondria: A Challenging Business
Pages 1-8
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Isolation and Quality Control of Functional Mitochondria
Pages 9-23
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Isolation of Mitochondria-Associated ER Membranes (MAMs) and Glycosphingolipid-Enriched Microdomains (GEMs) from Brain Tissues and Neuronal Cells
Pages 25-33
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Fluorescence Analysis of Single Mitochondria with Nanofluidic Channels
Pages 35-46
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Optical Microwell Arrays for Large-Scale Studies of Single Mitochondria Metabolic Responses
Pages 47-58
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Table of contents (38 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Mitochondrial Medicine
- Book Subtitle
- Volume I, Probing Mitochondrial Function
- Editors
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- Volkmar Weissig
- Marvin Edeas
- Series Title
- Methods in Molecular Biology
- Series Volume
- 1264
- Copyright
- 2015
- Publisher
- Humana Press
- Copyright Holder
- Springer Science+Business Media New York
- eBook ISBN
- 978-1-4939-2257-4
- DOI
- 10.1007/978-1-4939-2257-4
- Hardcover ISBN
- 978-1-4939-2256-7
- Softcover ISBN
- 978-1-4939-5572-5
- Series ISSN
- 1064-3745
- Edition Number
- 1
- Number of Pages
- XXV, 480
- Number of Illustrations
- 42 b/w illustrations, 66 illustrations in colour
- Topics
