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Epistasis

Methods and Protocols

  • Book
  • © 2015

Overview

Editors:
  1. Jason H. Moore

    1. Department of Genetics, Institute of Quantitative Biomedical Sciences, Geisel School of Medicine, Hanover, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Scott M. Williams

    1. Department of Genetics, Institute of Quantitative Biomedical Sciences, Geisel School of Medicine, Hanover, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 1253)

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Table of contents (18 protocols)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Long-Term Selection Experiments: Epistasis and the Response to Selection

    • Charles Goodnight
    Pages 1-18

  3. Finding the Epistasis Needles in the Genome-Wide Haystack

    • Marylyn D. Ritchie
    Pages 19-33

  4. Biological Knowledge-Driven Analysis of Epistasis in Human GWAS with Application to Lipid Traits

    • Li Ma, Alon Keinan, Andrew G. Clark
    Pages 35-45

  5. Epistasis for Quantitative Traits in Drosophila

    • Trudy F. C. Mackay
    Pages 47-70

  6. Epistasis in the Risk of Human Neuropsychiatric Disease

    • Scott M. Williams
    Pages 71-93

  7. On the Partitioning of Genetic Variance with Epistasis

    • José M. Álvarez-Castro, Arnaud Le Rouzic
    Pages 95-114

  8. Measuring Gene Interactions

    • Thomas F. Hansen
    Pages 115-143

  9. Two Rules for the Detection and Quantification of Epistasis and Other Interaction Effects

    • Günter P. Wagner
    Pages 145-157

  10. Direct Approach to Modeling Epistasis

    • Rong-Cai Yang
    Pages 159-183

  11. Capacitating Epistasis—Detection and Role in the Genetic Architecture of Complex Traits

    • Mats E. Pettersson, Örjan Carlborg
    Pages 185-196

  12. Compositional Epistasis: An Epidemiologic Perspective

    • Etsuji Suzuki, Tyler J. VanderWeele
    Pages 197-216

  13. Identification of Genome-Wide SNP–SNP and SNP–Clinical Boolean Interactions in Age-Related Macular Degeneration

    • Carlos Riveros, Renato Vimieiro, Elizabeth G. Holliday, Christopher Oldmeadow, Jie Jin Wang, Paul Mitchell et al.
    Pages 217-255

  14. Epistasis Analysis Using Information Theory

    • Jason H. Moore, Ting Hu
    Pages 257-268

  15. Genome-Wide Epistasis and Pleiotropy Characterized by the Bipartite Human Phenotype Network

    • Christian Darabos, Jason H. Moore
    Pages 269-283

  16. Network Theory for Data-Driven Epistasis Networks

    • Caleb A. Lareau, Brett A. McKinney
    Pages 285-300

  17. Epistasis Analysis Using Multifactor Dimensionality Reduction

    • Jason H. Moore, Peter C. Andrews
    Pages 301-314

  18. Epistasis Analysis Using ReliefF

    • Jason H. Moore
    Pages 315-325

  19. Epistasis Analysis Using Artificial Intelligence

    • Jason H. Moore, Doug P. Hill
    Pages 327-346

  20. Back Matter

    Pages 347-350
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Keywords

About this book

This volume presents a valuable and readily reproducible collection of established and emerging techniques on modern genetic analyses. Chapters focus on statistical or data mining analyses, genetic architecture, the burden of multiple testing, genetic variance, measuring epistasis, multifactor dimensionality reduction, and ReliefF. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Epistasis: Methods and Protocols aids scientists in continuing to study elucidate epistasis in the context of modern data availability.

Editors and Affiliations

  • Department of Genetics, Institute of Quantitative Biomedical Sciences, Geisel School of Medicine, Hanover, USA

    Jason H. Moore, Scott M. Williams

Bibliographic Information

  • Book Title: Epistasis

  • Book Subtitle: Methods and Protocols

  • Editors: Jason H. Moore, Scott M. Williams

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-2155-3

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2015

  • Hardcover ISBN: 978-1-4939-2154-6Published: 17 November 2014

  • Softcover ISBN: 978-1-4939-4275-6Published: 22 September 2016

  • eBook ISBN: 978-1-4939-2155-3Published: 17 November 2014

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: X, 350

  • Number of Illustrations: 44 b/w illustrations, 17 illustrations in colour

  • Topics: Human Genetics

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