Molecular Genetics of Dysregulated pH Homeostasis

Editors: Chi, Jen-Tsan (Ed.)

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  • Covers the relevance of dysregulated pH in a wide variety of human diseases
  • First title to cover molecular genetic analysis of dysregulated pH homeostasis
  • Summarizes the molecular genetics on the detailed mechanisms by which different mammalian cells sense and response acidity
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  • ISBN 978-1-4939-1683-2
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Hardcover $119.99
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  • ISBN 978-1-4939-1682-5
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Softcover $119.99
price for USA in USD
  • ISBN 978-1-4939-5317-2
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  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
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About this book

Most biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological functional at every level, including protein folding, enzymatic activities and proliferation and cell death. Therefore, maintain the pH homeostasis at the local or systemic level is one of the highest priorities for all multicellular organisms. Many redundant mechanisms are in place to maintain the pH homeostasis, a topic that is well covered in the scientific literature and medical textbooks. However, when the pH homeostasis is disrupted in various physiological adaptations and pathological situations, resulting acidity may trigger significant pathophysiological events and modulate disease outcomes. Therefore, understanding how various cells sense and react to acidity have broad impact in a wide variety of human diseases, including cancer, stroke, myocardial infarction and diabetes, renal and infectious diseases. In this book, many investigators have summarized the molecular genetics on the detailed mechanisms by which different mammalian cells sense and response acidity. These chapters cover the acidity with broad impact in biological understanding and human diseases and review various sensing mechanism and cellular responses to pH alterations in both physiological (taste, pain) and pathological settings (ischemia and cancers). Furthermore, these authors present a broad spectrum of investigative approaches to cellular response to acidosis in a in wide variety of human diseases.

Table of contents (8 chapters)

Table of contents (8 chapters)
  • Introduction: Molecular Genetics of Acid Sensing and Response

    Pages 1-7

    Lin, Chao-Chieh (et al.)

  • The Molecular Mechanism of Cellular Sensing of Acidity

    Pages 11-25

    O’Bryant, Zaven (et al.)

  • The Molecular Basis of Sour Sensing in Mammals

    Pages 27-43

    Ho, Jianghai (et al.)

  • Function and Signaling of the pH-Sensing G Protein-Coupled Receptors in Physiology and Diseases

    Pages 45-65

    Dong, Lixue (et al.)

  • Response to Acidity: The MondoA–TXNIP Checkpoint Couples the Acidic Tumor Microenvironment to Cell Metabolism

    Pages 69-100

    Ye, Zhizhou (et al.)

Buy this book

eBook $89.00
price for USA in USD
  • ISBN 978-1-4939-1683-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $119.99
price for USA in USD
  • ISBN 978-1-4939-1682-5
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $119.99
price for USA in USD
  • ISBN 978-1-4939-5317-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Genetics of Dysregulated pH Homeostasis
Editors
  • Jen-Tsan Chi
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4939-1683-2
DOI
10.1007/978-1-4939-1683-2
Hardcover ISBN
978-1-4939-1682-5
Softcover ISBN
978-1-4939-5317-2
Edition Number
1
Number of Pages
VIII, 160
Number of Illustrations
4 b/w illustrations, 12 illustrations in colour
Topics