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Mass Spectrometry Imaging of Small Molecules

  • Book
  • © 2015

Overview

Editors:
  1. Lin He

    1. Department of Chemistry, North Carolina State University, Raleigh, USA

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1203)

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Table of contents (19 protocols)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Current Status and Future Prospects of Mass Spectrometry Imaging of Small Molecules

    • Victoria L. Brown, Lin He
    Pages 1-7

  3. Sample Preparation for 3D SIMS Chemical Imaging of Cells

    • Nicholas Winograd, Anna Bloom
    Pages 9-19

  4. TOF-SIMS Imaging of Lipids on Rat Brain Sections

    • David Touboul, Alain Brunelle
    Pages 21-27

  5. MALDI-MS-Assisted Molecular Imaging of Metabolites in Legume Plants

    • Erin Gemperline, Lingjun Li
    Pages 29-40

  6. MALDI Mass Spectrometry Imaging of Lipids and Primary Metabolites on Rat Brain Sections

    • David Touboul, Alain Brunelle
    Pages 41-48

  7. Multiplex MALDI-MS Imaging of Plant Metabolites Using a Hybrid MS System

    • Andrew R. Korte, Gargey B. Yagnik, Adam D. Feenstra, Young Jin Lee
    Pages 49-62

  8. DESI Imaging of Small Molecules in Biological Tissues

    • Elaine C. Cabral, Demian R. Ifa
    Pages 63-77

  9. Desorption Electrospray Ionization Imaging of Small Organics on Mineral Surfaces

    • Rachel V. Bennett, Facundo M. Fernández
    Pages 79-89

  10. Imaging of Plant Materials Using Indirect Desorption Electrospray Ionization Mass Spectrometry

    • Christian Janfelt
    Pages 91-97

  11. Imaging of Lipids and Metabolites Using Nanospray Desorption Electrospray Ionization Mass Spectrometry

    • Ingela Lanekoff, Julia Laskin
    Pages 99-106

  12. Electrospray Laser Desorption Ionization (ELDI) Mass Spectrometry for Molecular Imaging of Small Molecules on Tissues

    • Min-Zong Huang, Siou-Sian Jhang, Jentaie Shiea
    Pages 107-116

  13. Automated Cell-by-Cell Tissue Imaging and Single-Cell Analysis for Targeted Morphologies by Laser Ablation Electrospray Ionization Mass Spectrometry

    • Hang Li, Brian K. Smith, Bindesh Shrestha, László Márk, Akos Vertes
    Pages 117-127

  14. Laser Ablation Sample Transfer for Mass Spectrometry Imaging

    • Sung-Gun Park, Kermit K. Murray
    Pages 129-139

  15. Nanostructure Imaging Mass Spectrometry: The Role of Fluorocarbons in Metabolite Analysis and Yoctomole Level Sensitivity

    • Michael E. Kurczy, Trent R. Northen, Sunia A. Trauger, Gary Siuzdak
    Pages 141-149

  16. Nanostructure-Initiator Mass Spectrometry (NIMS) for Molecular Mapping of Animal Tissues

    • Tara N. Moening, Victoria L. Brown, Lin He
    Pages 151-157

  17. Nanoparticle-Assisted Laser Desorption/Ionization for Metabolite Imaging

    • Michihiko Waki, Eiji Sugiyama, Takeshi Kondo, Keigo Sano, Mitsutoshi Setou
    Pages 159-173

  18. Matrix-Enhanced Surface-Assisted Laser Desorption/Ionization Mass Spectrometry (ME-SALDI-MS) for Mass Spectrometry Imaging of Small Molecules

    • Victoria L. Brown, Qiang Liu, Lin He
    Pages 175-184

  19. Laser Desorption Postionization Mass Spectrometry Imaging of Biological Targets

    • Artem Akhmetov, Chhavi Bhardwaj, Luke Hanley
    Pages 185-194

  20. Data Processing and Analysis for Mass Spectrometry Imaging

    • Jiangjiang Liu, Xingchuang Xiong, Zheng Ouyang
    Pages 195-209
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Keywords

About this book

This  volume presents new developments in the field of mass spectrometry imaging, covering imaging, software,  data analysis, new instrumentations, and new methodological approaches. Chapters provide detailed operational instructions from sample preparation to method selection, from comparative quantification to structural identification and from data collection to visualization of small molecule mapping in complex samples. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 Authoritative and cutting-edge, Mass Spectrometry Imaging of Small Molecules aims to  to bring the rapidly maturing methods of metabolic imaging to life science researchers and to minimize technical intimidation in adapting new technological platforms in biological research.

Reviews

“The purpose is to detail the rapidly maturing methods of metabolic imaging and to minimize technical challenges in adapting new technological platforms in biological research. These are quite worthy objectives that the book meets. The intended audience is life science researchers. The book also will be quite useful for students and scientists interested in learning more about mass spectrometry imaging of small molecules.” (Omer Iqbal, Doody’s Book Reviews, September, 2015)

Editors and Affiliations

  • Department of Chemistry, North Carolina State University, Raleigh, USA

    Lin He

Bibliographic Information

  • Book Title: Mass Spectrometry Imaging of Small Molecules

  • Editors: Lin He

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-1357-2

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2015

  • Hardcover ISBN: 978-1-4939-1356-5Published: 01 November 2014

  • Softcover ISBN: 978-1-4939-5408-7Published: 22 September 2016

  • eBook ISBN: 978-1-4939-1357-2Published: 31 October 2014

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 213

  • Number of Illustrations: 13 b/w illustrations, 57 illustrations in colour

  • Topics: Imaging / Radiology, Biological Microscopy, Spectroscopy/Spectrometry

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