Advances in Experimental Medicine and Biology

Systems Biology of RNA Binding Proteins

Editors: Yeo, Eugene W. (Ed.)

Free Preview
  • Provides case studies of RNA binding proteins that regulate aspects of RNA processing
  • Focuses on global protein-RNA interactions to understand disease and development
  • First book on systems biology of RNA Binding Proteins
see more benefits

Buy this book

eBook $139.00
price for USA in USD
  • ISBN 978-1-4939-1221-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-1-4939-1220-9
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $179.99
price for USA in USD
  • ISBN 978-1-4939-5434-6
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
About this book

After transcription in the nucleus, RNA binding proteins (RBPs) recognize cis-regulatory RNA elements within pre-mRNA sequence to form mRNA-protein (mRNP) complexes. Similarly to DNA binding proteins such as transcription factors that regulate gene expression by binding to DNA elements in the promoters of genes, RBPs regulate the fate of target RNAs by interacting with specific sequences or RNA secondary structural features within the transcribed RNA molecule. The set of functional RNA elements recognized by RBPs within target RNAs and which control the temporal, functional and spatial dynamics of the target RNA define a putative “mRNP code”. These cis-regulatory RNA elements can be found in the 5’ and 3’ untranslated regions (UTRs), introns, and exons of all protein-coding genes. RNA elements in 5’ and 3’ UTRs are frequently involved in targeting RNA to specific cellular compartments, affecting 3’ end formation, controlling RNA stability and regulating mRNA translation. RNA elements in introns and exons are known to function as splicing enhancers or silencers during the splicing process from pre-mRNA to mature mRNA.

This book provides case studies of RNA binding proteins that regulate aspects of RNA processing that are important for fundamental understanding of diseases and development. Chapters include systems-level perspectives, mechanistic insights into RNA processing and RNA Binding proteins in genetic variation, development and disease. The content focuses on systems biology and genomics of RNA Binding proteins and their relation to human diseases.

Table of contents (13 chapters)

Table of contents (13 chapters)
  • Evolutionary Conservation and Expression of Human RNA-Binding Proteins and Their Role in Human Genetic Disease

    Pages 1-55

    Gerstberger, Stefanie (et al.)

  • The Functions and Regulatory Principles of mRNA Intracellular Trafficking

    Pages 57-96

    Bergalet, Julie (et al.)

  • RNA-Binding Proteins in Regulation of Alternative Cleavage and Polyadenylation

    Pages 97-127

    Zheng, Dinghai (et al.)

  • Functional Analysis of Long Noncoding RNAs in Development and Disease

    Pages 129-158

    Chen, Ling-Ling (et al.)

  • Piwi Proteins and piRNAs Step onto the Systems Biology Stage

    Pages 159-197

    Clark, Josef P. (et al.)

Buy this book

eBook $139.00
price for USA in USD
  • ISBN 978-1-4939-1221-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-1-4939-1220-9
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $179.99
price for USA in USD
  • ISBN 978-1-4939-5434-6
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Loading...

Bibliographic Information

Bibliographic Information
Book Title
Systems Biology of RNA Binding Proteins
Editors
  • Eugene W. Yeo
Series Title
Advances in Experimental Medicine and Biology
Series Volume
825
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-1221-6
DOI
10.1007/978-1-4939-1221-6
Hardcover ISBN
978-1-4939-1220-9
Softcover ISBN
978-1-4939-5434-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
X, 468
Number of Illustrations
2 b/w illustrations, 52 illustrations in colour
Topics