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Aging and Heart Failure

Mechanisms and Management

  • Book
  • © 2014

Overview

Editors:
  1. Bodh I. Jugdutt

    1. Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta and Hospitals, Edmonton, Canada

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  • Valuable resource on molecular mechanisms of heart failure related to aging and current status of therapies for heart failure in the elderly

  • Provides critical assessment of publications on key topics by leading investigators in the field with emphasis on translational research and therapeutic implications

  • Addresses potential novel strategies that should receive attention for translating basic research knowledge into clinical application in patients

  • Includes supplementary material: sn.pub/extras

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Table of contents (32 chapters)

  1. Front Matter

    Pages i-xxii
    Download chapter PDF

  2. Changing Demographics of the Aging Population with Heart Failure and Implications for Therapy

    • Bodh I. Jugdutt
    Pages 1-14

  3. Biology of Aging and Implications for Heart Failure Therapy and Prevention

    • Bodh I. Jugdutt
    Pages 15-33

  4. Hypertension and Prevention of Diastolic Heart Failure in the Aging Population

    • Wilbert S. Aronow, Maciej Banach, Ali Ahmed
    Pages 35-45

  5. Aging and Optimal Therapy of Systolic Heart Failure in the Elderly

    • Nakul Chander Sharma, Bodh I. Jugdutt
    Pages 47-63

  6. Atrial Fibrillation and Heart Failure in the Aging Population

    • Pedram Kazemian, Bodh I. Jugdutt
    Pages 65-84

  7. Optimizing Therapy of Heart Failure in the Aging Population with Monitoring in Clinics

    • John R. Dimitry, Justin A. Ezekowitz
    Pages 85-93

  8. Cardiac Alterations in Aging, Hypertension, and Diastolic Heart Failure

    • Edith Pituskin, D. Ian Paterson
    Pages 95-106

  9. Polypharmacy and Adverse Drug Reactions in the Aging Population with Heart Failure

    • Michael W. Rich, William J. Nienaber
    Pages 107-116

  10. Age-Related Changes in Vascular Biology and Implications for Heart Failure Therapy in the Aging Population

    • Michael Sean McMurtry
    Pages 117-134

  11. Biomarkers and Optimal Management of Heart Failure in the Aging Population

    • Hanna K. Gaggin, James L. Januzzi Jr.
    Pages 135-146

  12. Benefits of Exercise in the Elderly

    • Ezra A. Amsterdam, C. Tissa Kappagoda
    Pages 147-164

  13. The RAAS in Heart Failure: An Update on Clinical Trials and Opportunities for Therapy

    • C. Tissa Kappagoda, Ezra A. Amsterdam
    Pages 165-182

  14. Aging and Diastolic Dysfunction: The Interplay of Inflammation and Extracellular Matrix Regulation

    • Peter Moritz Becher, Dirk Westermann, Carsten Tschöpe
    Pages 183-198

  15. Reperfusion and Vasodilator Therapy in Elderly Patients with STEMI and Heart Failure: Improving Outcomes

    • Bodh I. Jugdutt, Anwar Jelani, Seraj Abualnaja, Nakul Chander Sharma, Joseph Szeman Wong
    Pages 199-220

  16. Erythropoietin Therapy for Heart Failure

    • Margarita Borovka, Mathew S. Maurer
    Pages 221-241

  17. Role of Resistin in Heart Failure in the Elderly

    • Yasuchika Takeishi
    Pages 243-247

  18. Role of Coronary Artery Calcium in Cardiovascular Risk Stratification and Management in the Aging Population

    • Craig R. Butler, Paolo Raggi
    Pages 249-257

  19. Aging and Remodeling of the RAS and RAAS and Related Pathways: Implications for Heart Failure Therapy

    • Bodh I. Jugdutt
    Pages 259-289

  20. Aging and Right Ventricular Failure from Pulmonary Hypertension: Effect of Right Ventricular and Pulmonary Artery Remodeling

    • Joseph Szeman Wong, Bodh I. Jugdutt
    Pages 291-304
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Keywords

About this book

This book synthesizes the major research advances in molecular, biochemical and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactions in the aging population with heart failure; changes in the heart that accompany advancing age from humans to molecules; aging-associated alterations in myocardial inflammation and fibrosis and aging-related changes in mitochondrial function and implications for heart failure therapy. The book succinctly summarizes the large volume of data on these key topics and highlights novel pathways that need to be explored. Featuring contributions from leading clinician-scientists, Aging and Heart Failure: Mechanisms and Management is an authoritative resource on the major clinical issues in heart failure therapy in the elderly for cardiologists, gerontologists and internists.

Editors and Affiliations

  • Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta and Hospitals, Edmonton, Canada

    Bodh I. Jugdutt

Bibliographic Information

  • Book Title: Aging and Heart Failure

  • Book Subtitle: Mechanisms and Management

  • Editors: Bodh I. Jugdutt

  • DOI: https://doi.org/10.1007/978-1-4939-0268-2

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-4939-0267-5Published: 21 February 2014

  • Softcover ISBN: 978-1-4939-4423-1Published: 03 September 2016

  • eBook ISBN: 978-1-4939-0268-2Published: 19 February 2014

  • Edition Number: 1

  • Number of Pages: XXII, 475

  • Number of Illustrations: 34 b/w illustrations, 50 illustrations in colour

  • Topics: Cardiology, Geriatrics/Gerontology, Internal Medicine

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