Chemical Carcinogenesis

1. Front Matter

   Pages i-xv

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2. Xenobiotics: Metabolism and Interaction with Cellular Macromolecules

   1. Front Matter

      Pages 1-1

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   2. Cytochrome P-450 Function Analyses with Monoclonal Antibodies and cDNA Expression Vectors

      • Harry V. Gelboin, Frank J. Gonzalez, Sang S. Park, Junji Sagara, Narayana Battula

      Pages 3-15

   3. Cytochromes P-450 as Determinants of Susceptibility to Carcinogenesis by Aromatic Amines and Nitroaromatic Hydrocarbons

      • Fred F. Kadlubar, F. Peter Guengerich, Mary Ann Butler, K. Barry Delclos

      Pages 17-23

   4. Species-Dependent Differences in the Metabolic Activation of Polycyclic Aromatic Hydrocarbons in Cells in Culture

      • William M. Baird, Teresa A. Smolarek, Said M. Sebti, Donna Pruess-Schwartz

      Pages 25-36

   5. Complex Metabolic Activation Pathways of Polycyclic Aromatic Hydrocarbons: 3-Hydroxy-trans-7,8-Dihydroxy-7,8-Dihydrobenzo[a]Pyrene as a Proximate Mutagen of 3-Hydroxybenzo[a]Pyrene

      • Hansruedi Glatt, Paul C. Hirom, Charles A. Kirkby, Odartey Ribeiro, Albrecht Seidel, Franz Oesch

      Pages 37-44

   6. Carcinogenicity of Methyl Halides: Current Problems Concerning Chloromethane

      • Hermann M. Bolt, Hans Peter, Rainer Jäger

      Pages 45-51

   7. Relationship Between Structure and Mutagenic/Carcinogenic Activity of Short Chain Aliphatic Halocompounds: A Collaborative Project

      • Giorgio Cantelli-Forti, G. L. Biagi, P. A. Borea, G. Bronzetti, M. C. Guerra, P. Hrelia et al.

      Pages 53-65

   8. Enzymatic Detoxication of Tumorigenic Bay-Region Diol-Epoxides of Polycyclic Aromatic Hydrocarbons by Conjugation with Glutathione

      • Bengt Jernström, Iain G. C. Robertson, Bengt Mannervik, Lennart Dock

      Pages 67-73

   9. Antigenotoxic and Anticarcinogenic Effects of Thiols. In Vitro Inhibition of the Mutagenicity of Drug Nitrosation Products and Protection of Rat Liver ADP-Ribosyl Transferase Activity

      • Silvio De Flora, Carmelo F. Cesarone, Carlo Bennicelli, Anna Camoirano, Domizio Serra, Monia Bagnasco et al.

      Pages 75-86

   10. Relationships between NADPH Content and Benzo(a)pyrene Metabolism in Normal and Glucose-6-Phosphate Dehydrogenase-Deficient Human Fibroblasts

       • Rosa Pascale, Lucia Daino, Maria E. Ruggiu, Maria G. Vannini, Renato Garcea, Serenella Frassetto et al.

       Pages 87-92

   11. Comparison of the Covalent Binding of Various Chloroethanes with Nucleic Acids

       • Giorgio Prodi, Annamaria Colacci, Sandro Grilli, Giovanna Lattanzi, Mario Mazzullo, Paola Turina

       Pages 93-102

   12. In Situ Detection of Hepatic AF-DNA Adduct Formation During Continuous Feeding of 0.02% Acetylaminofluorene and in Enzyme-Altered Foci Induced by Foyr Different Protocols

       • Henrik S. Huitfeldt, Henry C. Pitot, John M. Hunt, Jeffrey Baron, Miriam C. Poirier

       Pages 103-109

   13. Interaction of Activated N-Nitrosamines with DNA

       • Jamie R. Milligan, Laura Catz-Biro, Samim Hirani-Hojatti, Michael C. Archer

       Pages 111-117

   14. Antibodies Specific for DNA Components Modified by Chemical Carcinogens and Their Binding Efficiency to DNA Modified in Vivo and in Vitro with the Corresponding Carcinogens

       • Erik Kriek, Frederik J. van Schooten, Michel J. X. Hillebrand, Maarten C. Welling

       Pages 119-128

   15. Liver DNA Damage by Chemical Carcinogens: Role of Thyroid Hormones

       • Marco Presta, Marco Rusnati, Jeanette A. M. Maier, Giovanni Ragnotti

       Pages 129-135

   16. Activation of Urinary Bladder Carcinogens within the Target Organ

       • Luisa Airoldi, Marina Bonfanti, Cinzia Magagnotti, Roberto Fanelli

       Pages 137-142

   17. Lipid Peroxidation and Bioactivation of Halogenated Hydrocarbons in Rat Liver Mitochondria During Experimental Siderosis

       • Aldo Tomasi, Emanuele Albano, Barbara Botti, Francesco P. Corongiu, M. Assunta Dessì, Anna Iannone et al.

       Pages 143-151

   18. Lipid Peroxidation, Protein Thiols, Calcium Homeostasis and Imbalance of Antioxidant Systems in Bromobenzene Induced Liver Damage

       • Alessandro F. Casini, Emilia Maellaro, Alfonso Pompella, Marco Ferrali, Mario Comporti

       Pages 153-163

3. Developmental Stages of Carcinogenesis

   1. Front Matter

      Pages 165-165

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About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino­ genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.

• apoptosis
• cancer
• carcinogenesis
• cell
• cell culture
• etiology
• hormones
• liver
• liver tumor
• mutagen
• pathogenesis
• prevention
• surgery
• tumor
• tumorigenesis

• University of Sassari, Sassari, Italy

  Francesco Feo, Renato Garcea

• University of Cagliari, Cagliari, Italy

  Paolo Pani, Amedeo Columbano

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