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Chemical Carcinogenesis

Models and Mechanisms

Authors: Feo, Francisco, Pani, Paolo

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About this book

About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino­ genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.

Table of contents (47 chapters)

  • Cytochrome P-450 Function Analyses with Monoclonal Antibodies and cDNA Expression Vectors

    Gelboin, Harry V. (et al.)

    Pages 3-15

  • Cytochromes P-450 as Determinants of Susceptibility to Carcinogenesis by Aromatic Amines and Nitroaromatic Hydrocarbons

    Kadlubar, Fred F. (et al.)

    Pages 17-23

  • Species-Dependent Differences in the Metabolic Activation of Polycyclic Aromatic Hydrocarbons in Cells in Culture

    Baird, William M. (et al.)

    Pages 25-36

  • Complex Metabolic Activation Pathways of Polycyclic Aromatic Hydrocarbons: 3-Hydroxy-trans-7,8-Dihydroxy-7,8-Dihydrobenzo[a]Pyrene as a Proximate Mutagen of 3-Hydroxybenzo[a]Pyrene

    Glatt, Hansruedi (et al.)

    Pages 37-44

  • Carcinogenicity of Methyl Halides: Current Problems Concerning Chloromethane

    Bolt, Hermann M. (et al.)

    Pages 45-51

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4757-9640-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4757-9642-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Chemical Carcinogenesis
Book Subtitle
Models and Mechanisms
Authors
Copyright
1988
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4757-9640-7
DOI
10.1007/978-1-4757-9640-7
Softcover ISBN
978-1-4757-9642-1
Edition Number
1
Number of Pages
XV, 679
Topics