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Advances in Experimental Medicine and Biology

Atherosclerosis Drug Discovery

Editors: Day, Charles (Ed.)

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About this book

Although atherosclerosis is the leading cause of death in the so-called affluent societies, there is presently no drug in our pharmacologic armamentarium against disease to either prevent or reverse this insidious killer and debilitant of human lives. Because of this void the First Brook Lodge Symposium on Anti­ Atherosclerosis Drug Discovery was convened at Brook Lodge in Augusta, Michigan, August 13-15, 1975. The symposium was sponsored by The Upjohn Company and was international in scope, with investi­ gators attending from such countries as England, Japan, Belgium, and Italy. The symposium focused on the problems associated with the discovery and evaluation of new drugs effective in preventing or reversing atherosclerosis. The thrust of material is centered around animal models useful as tools in the search and evaluation of new drugs. Broadly categorized, the models are nonhuman primates, rabbits, rodents, quail, and tissue culture. The material is a mix of studies on serum lipids and, more importantly, of studies on the artery, irrespective of serum lipid levels. The prevention of arterial lesions, not reduction of serum lipids, is emphasized. A review of all anti-atherosclerotic agents, with the exception of hypolipidemic agents, is included in this volume of the proceedings of the symposium.

Table of contents (27 chapters)

Table of contents (27 chapters)
  • A Model for Therapeutic Interventions on Established Coronary Atherosclerosis in a Nonhuman Primate

    Pages 3-31

    Malinow, M. R. (et al.)

  • The Nonhuman Primates as Models for Studying Human Atherosclerosis: Studies on the Chimpanzee, the Baboon and the Rhesus Macacus

    Pages 33-64

    Blaton, V. (et al.)

  • Phylogenetic Variability of Serum Lipids and Lipoproteins in Nonhuman Primates Fed Diets with Different Contents of Dietary Cholesterol

    Pages 65-75

    Srinivasan, S. R. (et al.)

  • The Baboon in Atherosclerosis Research: Comparison with Other Species and Use in Testing Drugs Affecting Lipid Metabolism

    Pages 77-87

    Howard, A. N.

  • The Fine Structure of Nonatherosclerotic Intimal Thickening, of Developing, and of Regressing Atherosclerotic Lesions at the Bifurcation of the Left Coronary Artery

    Pages 89-108

    Stary, Herbert C. (et al.)

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4614-4618-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4757-9309-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Atherosclerosis Drug Discovery
Editors
  • Charles Day
Series Title
Advances in Experimental Medicine and Biology
Series Volume
67
Copyright
1976
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-4618-7
DOI
10.1007/978-1-4614-4618-7
Softcover ISBN
978-1-4757-9309-3
Series ISSN
0065-2598
Edition Number
1
Number of Pages
X, 467
Topics