Overview
- Editors:
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Charles E. Day
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Atherosclerosis Research, The Upjohn Company, Kalamazoo, USA
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Table of contents (27 chapters)
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Primate Models
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- M. R. Malinow, Phyllis McLaughlin, Lynne Papworth, H. K. Naito, Lena Lewis, W. P. McNulty
Pages 3-31
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- S. R. Srinivasan, C. C. Smith, B. Radhakrishnamurthy, R. H. Wolf, G. S. Berenson
Pages 65-75
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- Herbert C. Stary, Jack P. Strong
Pages 89-108
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- H. F. Hoff, R. L. Jackson, A. M. Gotto Jr.
Pages 109-120
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Rabbit Models
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Front Matter
Pages 121-121
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- David Kritchevsky, Shirley A. Tepper, Jon A. Story
Pages 143-147
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- Y. S. Kwak, K. T. Lee, D. N. Kim
Pages 149-167
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- J. Rodriguez, A. Catapano, G. C. Ghiselli, C. R. Sirtori
Pages 169-189
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- S. Ghosh, J. N. Finkelstein, D. B. Moss, J. S. Schweppe
Pages 191-204
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- Joseph D. Pool, John L. Gainer, Guy M. Chisolm III
Pages 205-211
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Rodent Models
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Front Matter
Pages 213-213
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- Paul E. Schurr, John R. Schultz, Charles E. Day
Pages 215-229
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- Charles E. Day, Paul E. Schurr, William E. Heyd, Daniel Lednicer
Pages 231-249
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- W. A. Phillips, J. M. Ratchford, J. R. Schultz
Pages 251-265
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- Nozomu Takeuchi, Masami Ito, Yuichi Yamamura
Pages 267-288
About this book
Although atherosclerosis is the leading cause of death in the so-called affluent societies, there is presently no drug in our pharmacologic armamentarium against disease to either prevent or reverse this insidious killer and debilitant of human lives. Because of this void the First Brook Lodge Symposium on Anti Atherosclerosis Drug Discovery was convened at Brook Lodge in Augusta, Michigan, August 13-15, 1975. The symposium was sponsored by The Upjohn Company and was international in scope, with investi gators attending from such countries as England, Japan, Belgium, and Italy. The symposium focused on the problems associated with the discovery and evaluation of new drugs effective in preventing or reversing atherosclerosis. The thrust of material is centered around animal models useful as tools in the search and evaluation of new drugs. Broadly categorized, the models are nonhuman primates, rabbits, rodents, quail, and tissue culture. The material is a mix of studies on serum lipids and, more importantly, of studies on the artery, irrespective of serum lipid levels. The prevention of arterial lesions, not reduction of serum lipids, is emphasized. A review of all anti-atherosclerotic agents, with the exception of hypolipidemic agents, is included in this volume of the proceedings of the symposium.
Editors and Affiliations
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Atherosclerosis Research, The Upjohn Company, Kalamazoo, USA
Charles E. Day