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Nephrotoxicity

In Vitro to In Vivo Animals to Man

  • Book
  • © 1989

Overview

Editors:
  1. P. H. Bach

    1. The Robens Institute of Industrial and Environmental Health and Safety, University of Surrey, Guildford, Surrey, UK

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  2. E. A. Lock

    1. ICI Central Toxicology Laboratory, Macclesfield, Cheshire, UK

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (116 chapters)

  1. Front Matter

    Pages i-xx
    Download chapter PDF

  3. Heavy Metal Toxicity

    1. Lead Induced Nephrotoxicity: Kidney Calcium as an Indicator of Tubular Injury

      • R. A. Goyer, C. R. Weinberg, W. M. Victery, C. R. Miller
      Pages 11-20

    2. Predicting the Kidney Burden of Toxic Metals

      • Gary L. Diamond, Thomas W. Clarkson, John B. Hursh, M. George Cherian
      Pages 21-31

    3. A Prospective Study of Proteinuria in Cadmium Workers

      • Harry Roels, Robert Lauwerys, Jean-Pierre Buchet, Alfred Bernard, Alfons Vos, Maurice Oversteyns
      Pages 33-36

    4. Red Blood Cell Negative Charges as an Index of the Glomerular Polyanion in Chronic Cadmium Poisoning

      • Alfred Bernard, Ali Ouled Amor, Harry Roels, Robert Lauwerys
      Pages 37-41

    5. Some Considerations on Critical Concentration of Cadmium for Renal Toxicity in Rats

      • Chiharu Tohyama, Naoko Sugihira, Kazuo T. Suzuki, Masataka Murakami, Hiroshi Saito
      Pages 43-49

    6. Historical Perspective on Cadmium-Induced Nephrotoxicity

      • Vera R. Porter, Dora B. Weiner
      Pages 51-57

    7. Cadmium May Predispose Mice to Immune Complex-Mediated Renal Injury: Another Possible Mechanism for Cadmium-Induced Nephrotoxicity

      • Donna L. Vredevoe, Louis Levy, David W. Knutson
      Pages 59-63

    8. Nephrotoxicity of Cadmium in Chickens

      • R. O. Blackburn, D. N. Prashad, C. Whitehead
      Pages 65-70

    9. Differential Effects of Cadmium and Mercury on Lysosomal Enzymes in the Kidney of Myxine Glutinosa

      • E. Elger, R. Sievers, B. Elger, C. J. Olbricht, H. Stolte
      Pages 71-74

    10. The Effects of Cadmium and Adriamycin on the Isolated Perfused Glomerulus of Myxine Glutinosa (Cyclostomata)

      • L. M. Fels, M.-M. Barbey, B. Elger, J. Abel, H. Stolte
      Pages 75-79

    11. Protective Effect of Low Concentrations of Mercury Against HgCl2-Induced Nephrotoxicity

      • J. C. Cal, F. Larue, P. Dormmua, J. Cambar
      Pages 81-83

    12. Induction of Antinuclear Antibodies by Mercuric Chloride in Mice

      • P. Hultman, S. Enestrom
      Pages 85-91

    13. Analysis of Unscheduled Dna Synthesis and S-Phase Synthesis in F344 Rat Kidney After in Vivo Treatment with Mercuric Chloride

      • K. Steinmetz, C. Hamilton, J. Bakke, M. Ramsey, J. Mirsalis
      Pages 93-97

    14. In Vitro and in Vivo HgCl2-Induced Nephrotoxicity Assessed by Tubular Enzymes Release

      • J. C. Cal, D. Nerlet, J. Cambar
      Pages 99-102

    15. Prevention and Reversal of Mercuric Chloride-Induced Increases in Renal Vascular Resistance by Captopril

      • Z. H. Endre, L. G. Nicholls, P. J. Ratcliffe, J. G. G. Ledingham
      Pages 103-106

    16. Regioselective Acute Tubular Necrosis in Renal Cortical Slices Following HgCl2 and K2Cr2O7: Localization and Transport Studies

      • C. E. Ruegg, A. J. Gandolfi, A. K. Brendel
      Pages 107-112

    17. In-Vivo Bone Lead Measurements and Renal Effects

      • H. J. Mason, L. J. Somervaille, D. R. Tennant, D. R. Chettle, M. C. Scott
      Pages 113-118

    18. Early Indicators of Lead Nephropathy

      • F. Khalil-Manesh, H. C. Gonick, E. Weiler, V. Rosen, L. Roche, A. Mutti et al.
      Pages 119-126
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Keywords

About this book

There has been a growing awareness that nephrotoxicity represents a key factor in human nephropathies, where, irrespective of the causative agent, only a few clinical end-effects are diagnosed. Thus nephropathies are generally classified as acute or chronic renal failure, malignancies or immunological changes. The weaknesses in diagnosing nephropathies arises because of the effective role the kidney plays in maintaining homeostasis, despite the fact that it has been extensively damaged. The frequencies of some type of chemically-induced acute renal failure is well documented, but the causes of chronic renal failure, malignancy, and other nephropathies are far more difficult to associate with a chemical aetiology. Many of the new therapeutic agents have important beneficial effects, but they are found to have marked nephrotoxic effects. Thus there is a growing urgency to increase the stringency of chemical safety evaluation for their potential nephrotoxic effects. This is strongly countered by the increased financial pressure to identify potentially nephrotoxic chemicals earlier in their development and humanitarian considerations to more closely relate animal test to the clinical situation. Part of the challenge may be achieved by the increasing use of in vitro techniques.

Editors and Affiliations

  • The Robens Institute of Industrial and Environmental Health and Safety, University of Surrey, Guildford, Surrey, UK

    P. H. Bach

  • ICI Central Toxicology Laboratory, Macclesfield, Cheshire, UK

    E. A. Lock

Bibliographic Information

  • Book Title: Nephrotoxicity

  • Book Subtitle: In Vitro to In Vivo Animals to Man

  • Editors: P. H. Bach, E. A. Lock

  • DOI: https://doi.org/10.1007/978-1-4757-2040-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1989

  • Softcover ISBN: 978-1-4757-2042-6Published: 09 March 2013

  • eBook ISBN: 978-1-4757-2040-2Published: 29 June 2013

  • Edition Number: 1

  • Number of Pages: XX, 765

  • Number of Illustrations: 174 b/w illustrations

  • Topics: Nephrology

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