Nephrotoxicity

In Vitro to In Vivo Animals to Man

Editors: Bach, Peter (Ed.)

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About this book

There has been a growing awareness that nephrotoxicity represents a key factor in human nephropathies, where, irrespective of the causative agent, only a few clinical end-effects are diagnosed. Thus nephropathies are generally classified as acute or chronic renal failure, malignancies or immunological changes. The weaknesses in diagnosing nephropathies arises because of the effective role the kidney plays in maintaining homeostasis, despite the fact that it has been extensively damaged. The frequencies of some type of chemically-induced acute renal failure is well documented, but the causes of chronic renal failure, malignancy, and other nephropathies are far more difficult to associate with a chemical aetiology. Many of the new therapeutic agents have important beneficial effects, but they are found to have marked nephrotoxic effects. Thus there is a growing urgency to increase the stringency of chemical safety evaluation for their potential nephrotoxic effects. This is strongly countered by the increased financial pressure to identify potentially nephrotoxic chemicals earlier in their development and humanitarian considerations to more closely relate animal test to the clinical situation. Part of the challenge may be achieved by the increasing use of in vitro techniques.

Table of contents (49 chapters)

  • Species Differences in Renal Structure and Function — Applications to Nephrotoxicity in Man

    Schmidt-Nielsen, Bodil

    Pages 1-10

  • Lead Induced Nephrotoxicity: Kidney Calcium as an Indicator of Tubular Injury

    Goyer, R. A. (et al.)

    Pages 11-20

  • Predicting the Kidney Burden of Toxic Metals

    Diamond, Gary L. (et al.)

    Pages 21-31

  • A Prospective Study of Proteinuria in Cadmium Workers

    Roels, Harry (et al.)

    Pages 33-36

  • Red Blood Cell Negative Charges as an Index of the Glomerular Polyanion in Chronic Cadmium Poisoning

    Bernard, Alfred (et al.)

    Pages 37-41

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4757-2040-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4757-2042-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Nephrotoxicity
Book Subtitle
In Vitro to In Vivo Animals to Man
Editors
  • Peter Bach
Copyright
1989
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4757-2040-2
DOI
10.1007/978-1-4757-2040-2
Softcover ISBN
978-1-4757-2042-6
Edition Number
1
Number of Pages
XX, 765
Number of Illustrations and Tables
174 b/w illustrations
Topics