Comparison of Type I and Type II Diabetes

1. Front Matter

   Pages i-xi

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2. Introduction

   1. Identification of Some Issues and Questions to be Answered in Comparing Type I and Type II Diabetes

      • Mladen Vranic

      Pages 1-15

3. Is the Present Classification Valid And Sufficient

   1. Basis of the Present Classification of Diabetes

      • Peter H. Bennett

      Pages 17-29

   2. Limitations and Problems of Diabetes Classification from an Epidemiological Point of View

      • H. Keen

      Pages 31-46

   3. Gestational Diabetes: Problems in Classification and Implications for Long-Range Prognosis

      • Norbert Freinkel, Boyd E. Metzger

      Pages 47-63

   4. Heterogeneity within Type II and Mody Diabetes

      • Stefan S. Fajans

      Pages 65-87

4. Genetics and Immunology

   1. The Genetics of Type I and Type II Diabetes: Analysis by Recombinant DNA Methodology

      • M. Alan Permutt, Teresa Andreone, John Chirgwin, Steve Elbein, Peter Rotwein, Matthew Orland

      Pages 89-106

   2. Immunological Aspects of Type 1 and 2 Diabetes Mellitus

      • Ake Lernmark, Steinunn Baekkeskov, Ivan Gerling, William Kastern, Caj Knutson, Birgitte Michelsen

      Pages 107-127

5. Pathophysiology and Metabolic Abnormalities

   1. Insulin-Stimulated Glucose Disposal in Patients with Type I (IDDM) and Type II (NIDDM) Diabetes Mellitus

      • Gerald M. Reaven

      Pages 129-136

   2. Pathophysiology of Insulin Secretion in Diabetes Mellitus

      • W. Kenneth Ward, James C. Beard, Jeffrey B. Halter, Daniel Porte Jr.

      Pages 137-158

   3. Internalization of Insulin: Structures Involved and Significance

      • Barry I. Posner, Masood N. Kahn, John J. M. Bergeron

      Pages 159-173

   4. Insulin Resistance in Non-Insulin Dependent (Type II) and Insulin Dependent (Type I) Diabetes Mellitus

      • Jerrold M. Olefsky, Robert R. Revers, Mel Prince, Robert R. Henry, William T. Garvey, John A. Scarlett et al.

      Pages 175-205

   5. Insulin-Mediated and Non-Insulin-Mediated Metabolic Effects of Gastroenteropancreatic Peptides in Type I and Type II Diabetes

      • J. Dupre, A. Baer, M. Lee, T. J. McDonald, J. Radziuk, N. W. Rodger et al.

      Pages 207-225

   6. New Probes to Study Insulin Resistance in Men; Futile Cycle and Glucose Turnover

      • Mladen Vranic, Alexandre Wajngot, Suad Efendic

      Pages 227-245

   7. New Methods for the Analysis of Insulin Kinetics in Vivo: Insulin Secretion, Degradation, Systemic Dynamics and Hepatic Extraction

      • J. Radziuk, T. Morishima

      Pages 247-276

   8. Atherosclerosis, the Major Complication of Diabetes

      • George Steiner

      Pages 277-297

6. Complications

   1. A Comparison of Kidney Disease in Type I and Type II Diabetes

      • S. Michael Mauer, Blanche M. Chavers

      Pages 299-303

   2. Diabetic Neuropathy

      • Peter James Dyck, Anthony Windebank, Hitoshi Yasuda, F. John Service, Robert Rizza, Bruce Zimmerman

      Pages 305-320

   3. The Wisconsin Epidemiologic Study of Diabetic Retinopathy a Comparison of Retinopathy in Younger and Older Onset Diabetic Persons

      • Ronald Klein, Matthew D. Davis, Scot E. Moss, Barbara E. K. Klein, David L. DeMets

      Pages 321-335

7. Conclusions

   1. Some Summarizing Thoughts

      • George F. Cahill Jr.

      Pages 337-342

Five years ago, a new system of classification of the various types of diabetes was proposed. This publication provides an inte­ grated picture of the latest information on the similarities and dissimilarites of two types of diabetes. It contains contributions from morphologists, physiologists, biochemists, immunologists, pathologists, geneticists, clinicians and epidemiologists. In the first section, the basis for the present classification and its limitations are discussed. In addition, there is a discussion of gestational diabetes and heterogeneity of some sub-classes of diabetes. The next section deals with genetics and immunology. The third section discusses abnormalities of insulin secretion and act ion on both the receptor and post . . . receptor levels. The role of gastrointestinal peptides in Type I and Type II diabetes is also considered. In the last section, both types of diabetes are compared with respect to diabetic complications. The closing sec­ tion summarizes the present status and offers a stimulating view of future development. We hope that this book will be a useful source of information for both researchers and practicing clinicians. M. Vranic G. steiner C. H. Hollenberg v ACKNOWLEDGEMENTS The symposium from which this volume arose (June 28-29, 1984) was organized by the Banting and Best Diabetes Centre, University of Toronto. We would like to express our appreciation to the following sponsors: Ames Educational Institute, Ayerst Laboratories, Becton Dickinson Canada Inc. , Canadian Soft Drink Association, Connaught Laboratories Limited, Connaught Novo Ltd. , Eli Lilly Canada Inc.

• Insulin
• Insulin Secretion
• diabetes

• Departments of Physiology and Medicine and Banting and Best Diabetes Centre, University of Toronto, Toronto, Canada

  Mladen Vranic, George Steiner

• Department of Medicine and Banting and Best Diabetes Centre, University of Toronto, Toronto, Canada

  Charles H. Hollenberg

• Division of Endocrinology and Metabolism, Toronto General Hospital, Toronto, Canada

  George Steiner

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