Advances in Experimental Medicine and Biology

Purine Metabolism in Man

Biochemistry and Pharmacology of Uric Acid Metabolism

Editors: Sperling, Oded (Ed.)

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About this book

Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari­ fication.

Table of contents (46 chapters)

  • The Kinetics of Intramolecular Distribution of 15N in Uric Acid Following Administration of 15N-Glycine: Preferential Labeling of N−(3+9) of Uric Acid in Primary Gout and a Reappraisal of the “Glutamine Hypothesis”

    Sperling, Oded (et al.)

    Pages 371-393

  • Hyperglutamatemia in Primary Gout

    Gutman, Alexander B. (et al.)

    Pages 395-399

  • Reduced Renal Ammoniagenesis in Primary Gout

    Gutman, Alexander B. (et al.)

    Pages 401-405

  • The Uptake of Glycine-14C into the Adenine and Guanine of DNA and Insoluble RNA of Human Leucocytes

    Chang, G.-N. (et al.)

    Pages 407-416

  • In Certain Physiological Stress Conditions on the Problem of Hyperuricemia

    Machtey, I. (et al.)

    Pages 419-421

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-1-4757-1433-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.99
price for USA in USD
  • ISBN 978-1-4757-1435-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Purine Metabolism in Man
Book Subtitle
Biochemistry and Pharmacology of Uric Acid Metabolism
Editors
  • Oded Sperling
Series Title
Advances in Experimental Medicine and Biology
Copyright
1974
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4757-1433-3
DOI
10.1007/978-1-4757-1433-3
Softcover ISBN
978-1-4757-1435-7
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XXV, 476
Topics