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Advances in Experimental Medicine and Biology

Purine Metabolism in Man

Biochemistry and Pharmacology of Uric Acid Metabolism

Editors: Sperling, Oded (Ed.)

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About this book

Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari­ fication.

Table of contents (62 chapters)

Table of contents (62 chapters)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-1-4757-1433-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.99
price for USA in USD
  • ISBN 978-1-4757-1435-7
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Purine Metabolism in Man
Book Subtitle
Biochemistry and Pharmacology of Uric Acid Metabolism
Editors
  • Oded Sperling
Series Title
Advances in Experimental Medicine and Biology
Series Volume
41
Copyright
1974
Publisher
Springer US
Copyright Holder
Springer Science+Business Media, LLC, part of Springer Nature
eBook ISBN
978-1-4757-1433-3
DOI
10.1007/978-1-4757-1433-3
Softcover ISBN
978-1-4757-1435-7
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XXV, 476
Topics