Advances in Experimental Medicine and Biology

Acid Proteases: Structure, Function, and Biology

Editors: Tang, Jordan (Ed.)

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About this book

In the past ten years, a number of proceedings of symposia on the structure and function of proteolytic enzymes have been pub­ lished. Their coverage of acid proteases has been limited, mainly due to the lack of significant new information on the structure of these enzymes. In the last four years, however, the primary and tertiary structures of a number of acid proteases have been deter­ mined, prompting the need to discuss the meanings of the old data and the possibilities for new experimentations. It was for this purpose that the "Conference on Acid Proteases: Structure, Function, and Biology" was organized. It took place at the University of Oklahoma on November 21-24, 1976. This book is a collection of the main lectures delivered at the Conference. Acid Proteases, by definition refers to a group of proteases having an optimal pH in acidic solutions. The classic examples are pepsin and chymosin. Some catalytic features are obviously shared by these proteases, most notably, their inhibition by pepstatin. The use of active center-directed inactivators such as diazoacetyl­ norleucine methyl ester and 1,2-epoxy-3-(p-nitrophenoxy)propane has shown that two catalytic aspartyl residues are present in most of these enzymes. These apparent cornmon features have prompted the suggestion by several investigators to name this group of enzymes "aspartyl proteases" or "carboxyl proteases".

Table of contents (20 chapters)

  • Comparison of the Primary Structures of Acidic Proteinases and of Their Zymogens

    Foltmann, Bent (et al.)

    Pages 3-22

  • X-Ray Crystallographic Studies of Pepsin

    Andreeva, N. S. (et al.)

    Pages 23-31

  • The Crystal Structure of an Acid Protease from Rhizopus Chinensis at 2.5 a Resolution

    Subramanian, E. (et al.)

    Pages 33-41

  • X-Ray Analysis and Circular Dichroism of the Acid Protease from Endothia Parasitica and Chymosin

    Jenkins, John (et al.)

    Pages 43-60

  • Penicillopepsin: 2.8 a Structure, Active Site Conformation and Mechanistic Implications

    Hsu, I-Nan (et al.)

    Pages 61-81

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4757-0719-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4757-0721-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Acid Proteases: Structure, Function, and Biology
Editors
  • Jordan Tang
Series Title
Advances in Experimental Medicine and Biology
Series Volume
92
Copyright
1977
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4757-0719-9
DOI
10.1007/978-1-4757-0719-9
Softcover ISBN
978-1-4757-0721-2
Series ISSN
0065-2598
Edition Number
1
Number of Pages
IX, 355
Number of Illustrations and Tables
52 b/w illustrations
Topics