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Biological Reactive Intermediates—II

Chemical Mechanisms and Biological Effects

  • Book
  • © 1982

Overview

Editors:
  1. Robert Snyder

    1. Rutgers University, Piscataway, USA

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  2. David J. Jollow

    1. Medical University of South Carolina, Charleston, USA

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  3. Dennis V. Parke

    1. University of Surrey, Guildford, Surrey, England

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  4. C. Gordon Gibson

    1. University of Surrey, Guildford, Surrey, England

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  5. James J. Kocsis

    1. Thomas Jefferson University, Philadelphia, USA

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  6. Charlotte M. Witmer

    1. Rutgers University, Piscataway, USA

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  7. Beatrice N. Engelsberg

    1. Rutgers University, Piscataway, USA

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  8. George F. Kalf

    1. Thomas Jefferson University, Philadelphia, USA

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  9. Stephen L. Longacre

    1. Medical University of South Carolina, Charleston, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 136)

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Table of contents (66 chapters)

  1. Front Matter

    Pages i-xx
    Download chapter PDF

  2. Formation and Disposition of Biological Reactive Intermediates

    1. Reactive Metabolites as Key Intermediates in Pharmacologic and Toxicologic Responses: Examples from Chemical Carcinogenesis

      • Elizabeth C. Miller, James A. Miller
      Pages 1-21

    2. Role of Mixed-Function Oxidases in the Formation of Biological Reactive Intermediates

      • Dennis V. Parke, Costas Ioannides
      Pages 23-38

    3. Fate of Epdxides

      • Franz Oesch
      Pages 39-52

    4. Roles of Udp-Glucuronosyltransferase in the Inactivation of Benzo(a)Pyrene

      • K. W. Bock, B. S. Bock-Hennig, W. Lilienblum, H. Pfeil, R. F. Volp
      Pages 53-73

    5. Influence of γ-Glutamyl Transpeptidase Inactivation on the Status of Extracellular Glutathione and Glutathione Conjugates

      • Donald J. Reed, William W. Ellis
      Pages 75-86

    6. Monooxygenase and Epoxide Hydrolase Regulation in Primary Fetal Rat Liver Cell Culture

      • J. E. Gielen, J. De Graeve, Fr. Goujon, P. Kremers, J. Van Cantfort
      Pages 87-98

    7. Biochemical Basis for Dose Response Relationships in Reactive Metabolite Toxicity

      • David J. Jollow, Stanley Roberts, Veronica Price, Carol Smith
      Pages 99-113

  3. Oxygen Activation in Xenobiotic Metabolism

    1. The Heme Protein P-450 in Oxygen Activation: Carbon Monoxide Inhibition and Photochemical Action Spectroscopy as Tools to Study Its Catalytic Role

      • Heinz Schleyer, Stuart Hamill, David Y. Cooper, Otto Rosenthal
      Pages 119-143

    2. Possible Mechanism of Coupled NADPH Oxidase and P-450 Monooxygenase Action

      • Ingela Jansson, John B. Schenkman
      Pages 145-163

    3. Ligand Complexes Generated during Cytochrome P-450 Dependent Metabolism

      • Michael R. Franklin
      Pages 165-177

    4. Studies on the Mechanism of Stimulation of Microsomal H2O2 Formation and Benzo(a)pyrene Hydroxylaton by Substrates and Flavone

      • A. G. Hildebrandt, C. Bergs, G. Heinemeyer, E. Schlede, I. Roots, B. Abbas-Ali et al.
      Pages 179-198

    5. Alkylation and Peroxidation Injury from Chemically Reactive Metabolites

      • J. R. Mitchell, G. B. Corcoran, C. V. Smith, H. Hughes, B. H. Lauterburg
      Pages 199-223

  4. Reactive Intermediates of Monocyclic Aromatic Hydrocarbons

    1. Relationship between Benzene Metabolism and Toxicity: A Proposed Mechanism for the Formation of Reactive Intermediates from Polyphenol Metabolites

      • Richard D. Irons, William F. Greenlee, Daniel Wierda, James S. Bus
      Pages 229-243

    2. Metabolic Correlates of Benzene Toxicity

      • Robert Snyder, Stephen L. Longacre, Charlotte M. Witmer, James J. Kocsis
      Pages 245-256

    3. Metabolism and Genotoxicity of Styrene

      • Harri Vainio, Hannu Norppa, Kari Hemminki, Marja Sorsa
      Pages 257-274

    4. Development of a Novel Method for Measuring Covalent Binding and Its Application to Investigations of Bromobenzene Hepatotoxicity

      • John G. Dent, James D. Sun
      Pages 275-285

    5. Biotransformation of Bromobenzene to Reactive Metabolites by Isolated Hepatocytes

      • Hjördis Thor, Sten-Åke Svensson, Pia Hartzell, Sten Orrenius
      Pages 287-299

  5. Short Communications

    1. Urinary Metabolites of Benzene in the Mouse

      • Stephen L. Longacre, James J. Kocsis, Charlotte M. Witmer, Robert Snyder
      Pages 307-317

    2. Multi-Step Metabolic Activation of Benzene in Rat Liver Microsomes

      • Anders Tunek, Franz Oesch
      Pages 319-329
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Keywords

Editors and Affiliations

  • Rutgers University, Piscataway, USA

    Robert Snyder, Charlotte M. Witmer, Beatrice N. Engelsberg

  • Medical University of South Carolina, Charleston, USA

    David J. Jollow, Stephen L. Longacre

  • University of Surrey, Guildford, Surrey, England

    Dennis V. Parke, C. Gordon Gibson

  • Thomas Jefferson University, Philadelphia, USA

    James J. Kocsis, George F. Kalf

Bibliographic Information

  • Book Title: Biological Reactive Intermediates—II

  • Book Subtitle: Chemical Mechanisms and Biological Effects

  • Editors: Robert Snyder, David J. Jollow, Dennis V. Parke, C. Gordon Gibson, James J. Kocsis, Charlotte M. Witmer, Beatrice N. Engelsberg, George F. Kalf, … Stephen L. Longacre

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4757-0674-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1982

  • Softcover ISBN: 978-1-4757-0676-5Published: 15 January 2014

  • eBook ISBN: 978-1-4757-0674-1Published: 14 November 2014

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XX, 846

  • Topics: Biochemistry, general

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