Advances in Experimental Medicine and Biology

The Basal Forebrain

Anatomy to Function

Editors: Napier, T. Celeste, Kalivas, Peter W., Hanin, Israel (Eds.)

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About this book

The basal forebrain has received considerable attention in recent years. This emphasis resulted from observations that the cortically projecting cholinergic neurons found in this region are critical for normal information processing. However, to achieve a complete understanding of such a complex function as "information processing" it is necessary to consider the basal forebrain not as an autonomous structure with a solitary task, but one that plays an integrative role; a structure that is connected intimately with many brain regions. This view evolved from the realization that the basal forebrain interfaces cognitive and reward functions with motor outputs. It is from this integrative and functional perspective that the present book was organized. The book is a unique collection of reports pertaining to the basal forebrain that encompasses a diversity of research approaches and techniques. It provides the reader with a progression of information that begins with anatomical descriptions of the afferent and efferent systems, stressing the integrative nature of various neurotransmitters located within the basal forebrain. The chapters focusing on anatomy are complemented by electrophysiologic studies that merge anatomical concepts with synaptic pharmacology and behavior. In vitro experiments demonstrate physiologic variations in anatomically identified neuronal subtypes and, together with in vivo techniques, provide pharmacologic descriptions of neuronal consequences to various neurotransmitter influences. Additional in vivo reports correlate changes in neuronal activity with specific motivational states and motor behaviors. These functional approaches culminate with behavioral studies that overview current understanding of basal forebrain involvement in mnemonic, reward, and motor processes.

Table of contents (27 chapters)

Table of contents (27 chapters)
  • Piecing together the Puzzle of Basal Forebrain Anatomy

    Pages 1-42

    Heimer, Lennart (et al.)

  • Afferents to Basal Forebrain Cholinergic Projection Neurons: An Update

    Pages 43-100

    Záborszky, Lászlo (et al.)

  • γ-Aminobutyric Acid and µ-Opioid Receptor Localization and Adaptation in the Basal Forebrain

    Pages 101-117

    Churchill, Lynn (et al.)

  • Calcium-Binding Protein (Calbindin D-28k) Immunoreactive Neurons in the Basal Forebrain of the Monkey and the Rat: Relationship with the Cholinergic Neurons

    Pages 119-126

    Chang, Howard T. (et al.)

  • Glutamate-Like Immunoreactivity is Present within Cholinergic Neurons of the Laterodorsal Tegmental and Pedunculopontine Nuclei

    Pages 127-142

    Clements, J. R. (et al.)

Buy this book

eBook $84.99
price for USA in USD
  • ISBN 978-1-4757-0145-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
The Basal Forebrain
Book Subtitle
Anatomy to Function
Editors
  • T. Celeste Napier
  • Peter W. Kalivas
  • Israel Hanin
Series Title
Advances in Experimental Medicine and Biology
Series Volume
295
Copyright
1991
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4757-0145-6
DOI
10.1007/978-1-4757-0145-6
Softcover ISBN
978-1-4757-0147-0
Series ISSN
0065-2598
Edition Number
1
Number of Pages
X, 504
Number of Illustrations
169 b/w illustrations, 3 illustrations in colour
Topics