Skip to main content
SpringerLink
Log in
Book cover

Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods

  • Book
  • © 1986

Overview

Editors:
  1. Mendel Friedman

    1. U.S. Department of Agriculture, Berkeley, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 199)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (31 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Protein Inhibitors of Serine Proteinases — Mechanism and Classification

    • Michael Laskowski Jr.
    Pages 1-17

  3. The Biological Functions and Physiological Effects of Ingested Inhibitors of Digestive Reactions

    • S. S. Rothman
    Pages 19-31

  4. Safety of Trypsin Inhibitors in the Diet: Effects on the Rat Pancreas of Long-Term Feeding of Soy Flour and Soy Protein Isolate

    • Michael R. Gumbmann, William L. Spangler, Glenda M. Dugan, Joseph J. Rackis
    Pages 33-79

  5. Dose Effects of Raw Soyabean Flour on Pancreatic Growth

    • R. G. H. Morgan, R. A. Crass, P. S. Oates
    Pages 81-89

  6. Enhancement of Pancreatic Carcinogenesis by Raw Soy Protein Isolate: Quantitative Rat Model and Nutritional Considerations

    • B. D. Roebuck
    Pages 91-107

  7. Pancreatic Carcinogenesis — the Potential of Cholecystokinin as a Cocarcinogen in the Hamster — Nitrosamine Model

    • Allan G. Howatson
    Pages 109-121

  8. Interaction of Dietary Protein and Trypsin Inhibitor on Plasma Cholecystokinin and Pancreatic Growth in Rats

    • Gary M. Green, Van H. Levan, Rodger A. Liddle
    Pages 123-132

  9. Gastrin and Cholecystokinin Levels in Rats Fed Soya Bean Trypsin Inhibitor

    • Roman S. Temler, Christine Mettraux
    Pages 133-141

  10. Negative Feedback Inhibition of Pancreatic Exocrine Secretion in Humans

    • P. P. Toskes
    Pages 143-152

  11. Protease Inhibitors: Their Role as Modifiers of Carcinogenic Processes

    • Walter Troll, Krystyna Frenkel, Rakoma Wiesner
    Pages 153-165

  12. Nutritional and Metabolic Response to Plant Inhibitors of Digestive Enzymes

    • Daniel Gallaher, Barbara O. Schneeman
    Pages 167-184

  13. Pancreatic Response to Dietary Trypsin Inhibitor: Variations Among Species

    • Barbara O. Schneeman, Daniel Gallaher
    Pages 185-187

  14. The Effect of the Long-Term Feeding of Raw Soyflour on the Pancreas of the Mouse and Hamster

    • Irvin E. Liener, Aharon Hasdai
    Pages 189-197

  15. Accentuated Response to Soybean Inhibitors by Meal-Feeding in Various Species

    • Zafrira Nitsan, Israel Nir
    Pages 199-222

  16. Effect of Long-Term Feeding of Soy-Based Diets on the Pancreas of Cebus Monkeys

    • J. P. Harwood, L. M. Ausman, N. W. King, P. K. Sehgal, R. J. Nicolosi, I. E. Liener et al.
    Pages 223-237

  17. Inhibition of Human Proteinases by Grain Legumes

    • Juergen K. P. Weder
    Pages 239-279

  18. Regulation of Proteinase Inhibitor Genes in Food Plants

    • Willis E. Brown, John S. Graham, Jong S. Lee, Clarence A. Ryan
    Pages 281-290

  19. Genetics and Breeding of Soybeans Lacking the Kunitz Trypsin Inhibitor

    • Theodore Hymowitz
    Pages 291-298

  20. Protease Inhibitors in Plant Foods: Content and Inactivation

    • J. J. Rackis, W. J. Wolf, E. C. Baker
    Pages 299-347
Back to top

Keywords

About this book

Soybean protei ns are wi de 1 y used inhuman foods ina vari ety of forms, including baby formulas, flour, soy protein concentrates, soy protein isolates, soy sauces, textured soy fibers, and tofu. The presence of inhibitors of digestive enzymes in soy proteins impairs nutritional quality and possible safety of this impportant legume. Normal processing conditions based on the use of heat do not completely inactivate these inhibitors, so that residual amounts of plant protease inhibitors are consumed by animals and man. Inhibitors of digestive enzymes are present not only in legumes, such as soybeans, lima beans, and kidney beans, but also in nearly all plant foods, including cereals and potatoes, albeit in much smaller amounts. The antinutritional effects of inhibitors of proteolytic enzymes have been widely studied and can be ameliorated by processing and/or sulfur amino acid fortification. A more urgent concern is reports that rats fed diets containing even low levels of soybean-derived inhibitors, which are found in foods such as soy-based baby formulas, may develop over their lifespan pancreatic lesions leading eventually to neoplasia or tumor formation. On the other hand, recent stUdies suggest that certain enzyme inhibitors from plant foods may prevent cancer formation in other tissues. A key question, therefore, is whether inhibitors from plant foods constitute a human health hazard.

Editors and Affiliations

  • U.S. Department of Agriculture, Berkeley, USA

    Mendel Friedman

Bibliographic Information

  • Book Title: Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods

  • Editors: Mendel Friedman

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4757-0022-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1986

  • Softcover ISBN: 978-1-4757-0024-4Published: 22 December 2012

  • eBook ISBN: 978-1-4757-0022-0Published: 09 March 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XI, 572

  • Topics: Food Science

Publish with us

Policies and ethics

Back to top

Search

Navigation