Elastin and Elastic Tissue

1. Front Matter

   Pages i-xv

   PDF

2. Morphology of Elastin and Elastic Tissue

   1. Front Matter

      Pages 1-1

      PDF

   2. Introduction

      • William H. Carnes

      Pages 3-6

   3. The Morphogenesis of Elastic Fibers

      • Russell Ross, Philip J. Fialkow, Lawrence K. Altman

      Pages 7-17

   4. The Elastic System Fibers

      • G. Cotta-Pereira, F. Guerra Rodrigo, J. F. David-Ferreira

      Pages 19-30

   5. Ultrastructural Studies of Developing Pulmonary Alveolar Septal Elastin

      • Joshua A. Fierer, Joseph M. Cerreta, Ines Mandl, L. Stanley James

      Pages 31-37

   6. Ultrastructural Changes of Elastic Tissue in Hamster Lung During Elastase-Emphysema

      • Shiu Yeh Yu, C. N. Sun, Murtie F. Still

      Pages 39-56

   7. Elastic Tissue Histochemistry

      • D. A. Keith, M. A. Paz, P. M. Gallop

      Pages 57-60

   8. Conformation of Aortic Elastin Revealed by Scanning Electronmicroscopy of Dissected Surfaces

      • William H. Carnes, Mary Lou Hart, Norman M. Hodgkin

      Pages 61-70

   9. Scanning Electron Microscopy of Purified Elastin with and Without Enzymatic Digestion

      • Anna Kadar

      Pages 71-96

   10. The Ultrastructure and Mechanics of Elastic Ligaments

       • A. Serafini-Fracassini, J. M. Field, J. W. Smith, W. G. S. Stephens

       Pages 97-103

   11. Recent Observations on the Structure and Composition of Elastin

       • L. Gotte

       Pages 105-116

   12. Ultrastructure of Elastin Coacervates

       • D. Volpln

       Pages 119-128

   13. General Discussion on Morphology of Elastin and Elastic Tissue

       • Lawrence B. Sandberg, William R. Gray, Carl Franzblau

       Pages 129-136

3. Turnover and Elastolysis in Elastic Tissue

   1. Front Matter

      Pages 137-137

      PDF

   2. Introduction

      • L. Robert

      Pages 139-143

   3. Elastase-Like Enzymes in Aortas and Human Breast Carcinomas: Quantitative Variations with Age and Pathology

      • W. Hornebeck, L. Robert

      Pages 145-164

   4. Chymotrypsinogen D, A New Zymogen from Porcine Pancreas with Proelastolytic Activity

      • F. Lamy, D. Gibson, M. Ledoux, J. C. Moreux

      Pages 165-175

   5. Photolysis of Desmosine And Isodesmosine by Ultraviolet Light

      • F. Lamy, R. Bauraln, M. Guay, J. F. Larochelle

      Pages 177-187

   6. Factors Affecting the Proteolytic Degradation of Elastin

      • H. M. Kagan, R. E. Jordan, R. M. Lerch, D. P. Mukherjee, P. Stone, C. Franzblau

      Pages 189-207

Although elastin was first identified and purifled in 1840, relatively few, major advances to determine its structure and function occurred between then and 1970. This was pointed out by Carl Franzblau in his recent review (1). This sad state of affairs does not detract, however, from the importance of contributions made during the last 50 years; many of these are referred to in the various chapters that comprise this monograph. I would be remiss not to emphasize the pioneering work of S. M. Partridge, who, in 1955, reported on a technique to obtain virtually pure elastin. It was, indeed, a privilege to have the participation of Dr. Partridge in the First International Conference on Elastin, the proceedings of which constitute this volume. In 1974, the Division of Lung Diseases of the National Heart, Lung, and Blood Institute initiated a targeted research program on "Isolation and Purification of Lung Elastin". It was an asset to the program that it attracted eminent scientists who, in effect, stimulated a new wave of interest and activity in this neglected area of research. This resurgence of interest may have been due to the challenge of working with a tissue that presented difficulties which had in the past discour­ aged investigators. It soon became apparent that the research program initiated by the Division of Lung Diseases was attracting much interest and that many significant contributions would result from it.

• amino acid
• cell culture
• chemistry
• enzymes
• metabolism
• primary structure
• protein
• structure
• synthesis
• tissue
• wave

• University of Utah, Salt Lake City, USA

  Lawrence B. Sandberg, William R. Gray

• Boston University School of Medicine, Boston, USA

  Carl Franzblau

Policies and ethics