Vascular Endothelium

1. Front Matter

   Pages i-xii

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2. Properties of Endothelial Cell Plasmalemma

   1. Front Matter

      Pages 1-1

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   2. Structural Basis for Endothelial Cell Function: Role of Calcium, Polyphosphoinositide Turnover and G-Proteins

      • Una S. Ryan

      Pages 3-20

   3. Modulation of Endothelial Permeability: Role of Receptors, Second Messengers and Ion Channels

      • Søren-Peter Olesen

      Pages 21-27

   4. Factors Affecting the Fluidity of the Endothelial Cell Plasma Membrane

      • Edward R. Block

      Pages 29-42

   5. Vascular Endothelial Surface Proteins in the Perfused Rabbit Lung

      • C. Norman Gillis, Marilyn P. Merker, William W. Carley

      Pages 43-54

   6. Endothelial Specific Binding Sites for Permeant Plasma Macromolecules: Albumin Binding Proteins

      • Nicolae Simionescu, Maya Simionescu

      Pages 55-66

3. Receptors

   1. Front Matter

      Pages 67-67

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   2. Purine Receptors on Endothelial Cells

      • John L. Gordon

      Pages 69-75

   3. Muscarinic Receptors on Endothelial Cells

      • John D. Catravas, Alain B. Legrand, Una S. Ryan, Robert S. Aronstam

      Pages 77-88

   4. Comparison between Paf-Acether Receptors on Intact Washed Human Platelets and Human Endothelial Cells in Culture

      • Ruth Korth, M. Hirafuji, J. Bidault, B. Canton, F. Russo-Marie, J. Benveniste

      Pages 89-98

   5. Prostaglandins as Transducers of Proliferation Signals in Microvascular Endothelial Cells and the Pharmacological Control of Angiogenesis

      • Anthony C. Allison, W. Joseph Kowalski

      Pages 99-110

   6. The Role of Basement Membrane in Angiogenesis

      • Michael E. Maragoudakis

      Pages 111-120

   7. The Role of Cytokines in the Symbiotic Relationship between Leukocytes and Vascular Endothelia

      • Alberto Mantovani, Elisabetta Dejana

      Pages 121-127

   8. Response of Vascular Cells to Herpes Simplex Virus Infection

      • Nicholas A. Kefalides, Zahra Ziaie

      Pages 129-139

   9. Receptors for Extracellular Matrix Proteins in Endothelial Cells

      • Elisabetta Dejana, G. Conforti, A. Zanetti, M. G. Lampugnani, P. C. Marchisio

      Pages 141-147

   10. Cellular Distribution and Heterogeneity of Endothelial Cell Adhesion Receptors

       • Jan A. van Mourik, Jacques C. Giltay, Albert E. G. Kr. von dem Borne

       Pages 149-154

4. Messengers

   1. Front Matter

      Pages 155-155

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   2. Modulation of the Guanylate Cyclase -cGMP System by Vasodilators and the Role of Free Radicals as Second Messengers

      • Ferid Murad

      Pages 157-164

   3. Agonist Stimulated Changes in Human Endothelial Cell Cytosolic Calcium

      • Trevor J. Hallam, J. E. Merritt, T. J. Rink, R. Jacob

      Pages 165-172

Beyond their obvious role of a barrier between blood and tissue, vascular endothelial cells are now firmly established as active and essential participants in a host of crucial physiological and pathophysiological functions. Probably the two most important factors responsible for promoting the current knowledge of endothelial functions are 1) observations in the late sixties-early seventies that many non-ventilatory properties of the lung could be attributed to the pulmonary endothelium and 2) the establishment, in the early and mid-seventies of procedures for routine culture of vascular endothelial cells. Many of these endothelial functions require the presence of receptors on the surface of the plasma membrane. There is now evidence for the existence among others of muscarinic, a-and /3-adrenergic, purine, insulin, histamine, bradykinin, lipoprotein, thrombin, paf, fibronectin, vitronectin, interleukin and albumin receptors. For some of these ligands, there is evidence only for the existence of endothelial binding sites. Traditionally, agonist binding must elicit a response for the binding site to be considered a receptor and, in some cases, the nature of the response resulting from the interaction of a substance with the endothelium remains unclear. It is beyond the scope of this introduction to even enumerate the various endothelial homeostatic processes. This monograph contains the proceedings of the Advanced Studies Institute on "Vascular Endothelium: Receptors and Transduction Mechanisms" held in Porto Carras, Greece from June 18-29, 1988.

• Calcium
• Plasma
• Purine
• cell membrane
• cells
• cytokine
• endothelium
• lipoprotein
• pharmacology
• phosphorylation
• plasma membrane
• protein
• receptor
• receptors
• tissue

• Medical College of Georgia, Augusta, USA

  John D. Catravas

• Yale University School of Medicine, New Haven, USA

  C. Norman Gillis

• University of Miami School of Medicine, Miami, USA

  Una S. Ryan

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