Advances in Experimental Medicine and Biology

Excitatory Amino Acids and Epilepsy

Authors: Schwarcz, Robert, Ben-Ari, Yehezkel

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About this book

Human epilepsy is a major public health problem affecting approximately 2 persons per 1000. It is particularly frequent in ohildren where convul­ sions may lead to brain damage and subsequent seizure activity in adulthood. Temporal lobe epilepsy (synonyms include limbic epilepsy. psychomotor epilepsy and complex partial epilepsy) is the most devastating form of epilepsy in the adult population since: a) it is often extremely resistant to currently available anticonvulsant drugs (i.e •• it is more resistant than tonico-clonic or grand mal seizures) and b) it includes loss of consciousness. thereby limiting performance of many normal functions and leaving the individual susceptible to bodily injury. It is also associated with nerve cell loss. in particular in the hippocampus and other structures of the temporal lobes. In order to promote an appropriate therapy it is essential to understand the etiology of seizures and its relationship to brain damage. Basic research on epilepsy also provides a very useful vehicle to learn about the way the brain functions under normal conditions. For instance. much of our present understanding of the mechanisms of action of GABA and benzo­ diazepines. control of neuronal activity. etc. has been derived from such stUdies.

Table of contents (41 chapters)

  • Amygdalohippocampal and Amygdalocortical Projections in the Primate Brain

    Amaral, D. G.

    Pages 3-17

  • Subcortical Projections from the Amygdaloid Complex

    Price, J. L.

    Pages 19-33

  • Cortical and Subcortical Afferents of the Amygdaloid Complex

    Russchen, F. T.

    Pages 35-52

  • Putative Amino Acid Transmitters in the Amygdala

    Ottersen, O. P. (et al.)

    Pages 53-66

  • A Survey of the Anatomy of the Hippocampal Formation, with Emphasis on the Septotemporal Organization of Its Intrinsic and Extrinsic Connections

    Witter, M. P.

    Pages 67-82

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4684-7971-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4684-7973-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Excitatory Amino Acids and Epilepsy
Authors
Series Title
Advances in Experimental Medicine and Biology
Series Volume
203
Copyright
1986
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-7971-3
DOI
10.1007/978-1-4684-7971-3
Softcover ISBN
978-1-4684-7973-7
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XI, 735
Topics